Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)

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Accession:244262
"... High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) suppresses parkinsonian motor symptoms and modulates cortical activity. ... Cortical evoked potentials (cEP) generated by STN DBS reflect the response of cortex to subcortical stimulation, and the goal was to determine the neural origin of cEP using a two-step approach. First, we recorded cEP over ipsilateral primary motor cortex during different frequencies of STN DBS in awake healthy and unilateral 6-OHDA lesioned parkinsonian rats. Second, we used a biophysically-based model of the thalamocortical network to deconstruct the neural origin of the cEP. The in vivo cEP included short (R1), intermediate (R2) and long-latency (R3) responses. Model-based cortical responses to simulated STN DBS matched remarkably well the in vivo responses. R1 was generated by antidromic activation of layer 5 pyramidal neurons, while recurrent activation of layer 5 pyramidal neurons via excitatory axon collaterals reproduced R2. R3 was generated by polysynaptic activation of layer 2/3 pyramidal neurons via the cortico-thalamic-cortical pathway. Antidromic activation of the hyperdirect pathway and subsequent intracortical and cortico-thalamo-cortical synaptic interactions were sufficient to generate cEP by STN DBS, and orthodromic activation through basal ganglia-thalamus-cortex pathways was not required. These results demonstrate the utility of cEP to determine the neural elements activated by STN DBS that might modulate cortical activity and contribute to the suppression of parkinsonian symptoms."
Reference:
1 . Kumaravelu K, Oza CS, Behrend CE, Grill WM (2018) Model-based deconstruction of cortical evoked potentials generated by subthalamic nucleus deep brain stimulation. J Neurophysiol 120:662-680 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex; Thalamus;
Cell Type(s): Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; Hodgkin-Huxley neuron; Neocortex layer 4 neuron; Neocortex fast spiking (FS) interneuron; Neocortex primary motor area pyramidal layer 5 corticospinal cell;
Channel(s): I Na,p; I K; I Sodium; I_KD; I Calcium; I T low threshold; I L high threshold; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Deep brain stimulation; Evoked LFP;
Implementer(s): Kumaravelu, Karthik [kk192 at duke.edu];
Search NeuronDB for information about:  Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; AMPA; NMDA; Gaba; I Na,p; I L high threshold; I T low threshold; I K; I Sodium; I Calcium; I_AHP; I_KD; Gaba; Glutamate;
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cEP_stndbs_4.5hz
cells
dat
data_stndbs_4.5hz
hoc
net
readme.txt
alphasyndiffeq.mod *
alphasynkin.mod *
alphasynkint.mod *
ampa.mod *
ar.mod *
cad.mod *
cal.mod *
cat.mod *
cat_a.mod *
gabaa.mod *
iclamp_const.mod *
k2.mod *
ka.mod *
ka_ib.mod *
kahp.mod *
kahp_deeppyr.mod *
kahp_slower.mod *
kc.mod *
kc_fast.mod *
kdr.mod *
kdr_fs.mod *
km.mod *
naf.mod *
naf_tcr.mod *
naf2.mod *
nap.mod *
napf.mod *
napf_spinstell.mod *
napf_tcr.mod *
par_ggap.mod
pulsesyn.mod *
rampsyn.mod *
rand.mod *
ri.mod *
traub_nmda.mod *
balanal.hoc *
balcomp.hoc *
cell_templates.hoc *
clear.hoc *
finit.hoc *
fortmap.hoc *
gidcell.hoc *
gidcell.ses *
Iintra.dat
init_stndbs_4.5hz.hoc
manage_setup_stndbs_4.5hz.hoc
onecell.hoc *
onecell.ses *
perf.dat
prcellstate.hoc *
printcon.hoc *
run_stndbs_4.5hz.q
spkplt.hoc *
vclampg.hoc *
vcompclamp.hoc *
vcompsim.hoc *
                            
TITLE Potasium AHP (slower) type current for RD Traub, et al 2005

COMMENT
	Modified by Tom Morse to make slower than the slow suppyrFRB, suppyrRS AHP.
	Note the time constant at zero cai is 1 second here and 100ms in the slow AHP
	3/13/06
	Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu)
	RD Traub, J Neurophysiol 89:909-921, 2003
ENDCOMMENT

UNITS { 
	(mV) = (millivolt) 
	(mA) = (milliamp) 
	(mM) = (milli/liter)
} 

NEURON { 
	SUFFIX kahp_slower
	USEION k READ ek WRITE ik
	USEION ca READ cai
	RANGE gbar, ik, m
}

PARAMETER { 
	gbar = 0.0 	(mho/cm2)
	v		(mV) 
	ek 		(mV)  
	cai		(mM)
}
 
ASSIGNED { 
	ik 		(mA/cm2) 
	alpha (/ms) beta	(/ms)
}
 
STATE {
	m
}

BREAKPOINT { 
	SOLVE states METHOD cnexp
	ik = gbar * m * ( v - ek ) 
}
 
INITIAL { 
	rates( cai )
	m = alpha / ( alpha + beta )
	m = 0
}
 
DERIVATIVE states { 
	rates( cai )
	m' = alpha * ( 1 - m ) - beta * m 
}

UNITSOFF 

PROCEDURE rates(chi (mM)) { 

	if( cai < 500 ) {
		alpha = cai / 50000
	}else{
		alpha = 0.01
	}
	beta = 0.001
}

UNITSON

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