"A quantitative, physiology-based model of the ascending arousal system
is developed, using continuum neuronal population modeling, which
involves averaging properties such as firing rates across neurons in
each population. The model includes the ventrolateral preoptic area
(VLPO), where circadian and homeostatic drives enter the system, the
monoaminergic and cholinergic nuclei of the ascending arousal system,
and their interconnections. The human sleep-wake cycle is governed by
the activities of these nuclei, which modulate the behavioral state of
the brain via diffuse neuromodulatory projections.
The model behavior is robust across
the constrained parameter ranges, but with sufficient flexibility to
describe a wide range of observed phenomena.
Phillips AJ, Robinson PA (2007) A quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system. J Biol Rhythms 22:167-79 [PubMed]