DRG neuron models investigate how ion channel levels regulate firing properties (Zheng et al 2019)

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Accession:256632
We present computational models for an Abeta-LTMR (low-threshold mechanoreceptor) and a C-LTMR expressing four Na channels and four K channels to investigate how the expression level of Kv1 and Kv4 regulate number of spikes (repetitive firing) and onset latency to action potentials in Abeta-LTMRs and C-LTMRs, respectively.
Reference:
1 . Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD (2019) Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties Neuron
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Mouse;
Cell Type(s): Dorsal Root Ganglion (DRG) cell;
Channel(s): I Sodium; I Potassium; I K; I A;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.1 SCN1A; Nav1.6 SCN8A; Nav1.7 SCN9A; Nav1.8 SCN10A; Kv1.1 KCNA1; Kv1.2 KCNA2; Kv2.1 KCNB1; Kv3.1 KCNC1; Kv3.3 KCNC3; Kv3.4 KCNC4; Kv4.3 KCND3;
Transmitter(s):
Simulation Environment: NEURON; R;
Model Concept(s): Action Potential Initiation; Action Potentials; Activity Patterns; Delay; Ion Channel Kinetics; Membrane Properties;
Implementer(s): Zheng, Yang [zylittlep at gmail.com]; Bean, Bruce [bruce_bean at hms.harvard.edu];
Search NeuronDB for information about:  I A; I K; I Sodium; I Potassium;
create soma
access soma

soma nseg=1
soma diam=19.55 // calculated from Cm=12pF with diam=L
soma L=19.55  // calculated from Cm
soma Ra=1000 

soma insert leak
soma insert kv1
soma insert kv2
soma insert kv3
soma insert kv4
soma insert nav1p1
soma insert nav1p6
soma insert nav1p7
soma insert nav1p8
ek = -88
ena = 55

finitialize(-80)

gnabar_nav1p1 = 0
gnabar_nav1p6 = 0
gnabar_nav1p7 = 0.03
gnabar_nav1p8 = 0.04
gkbar_kv1 = 0.00006
gkbar_kv2 = 0.002
gkbar_kv3 = 0.00005
gkbar_kv4 = 0.011
g_leak = 0.00002

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