DRG neuron models investigate how ion channel levels regulate firing properties (Zheng et al 2019)

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Accession:256632
We present computational models for an Abeta-LTMR (low-threshold mechanoreceptor) and a C-LTMR expressing four Na channels and four K channels to investigate how the expression level of Kv1 and Kv4 regulate number of spikes (repetitive firing) and onset latency to action potentials in Abeta-LTMRs and C-LTMRs, respectively.
Reference:
1 . Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD (2019) Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties Neuron
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Mouse;
Cell Type(s): Dorsal Root Ganglion (DRG) cell;
Channel(s): I Sodium; I Potassium; I K; I A;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.1 SCN1A; Nav1.6 SCN8A; Nav1.7 SCN9A; Nav1.8 SCN10A; Kv1.1 KCNA1; Kv1.2 KCNA2; Kv2.1 KCNB1; Kv3.1 KCNC1; Kv3.3 KCNC3; Kv3.4 KCNC4; Kv4.3 KCND3;
Transmitter(s):
Simulation Environment: NEURON; R;
Model Concept(s): Action Potential Initiation; Action Potentials; Activity Patterns; Delay; Ion Channel Kinetics; Membrane Properties;
Implementer(s): Zheng, Yang [zylittlep at gmail.com]; Bean, Bruce [bruce_bean at hms.harvard.edu];
Search NeuronDB for information about:  I A; I K; I Sodium; I Potassium;
proc nav1p1param(){         
print   "vhminf_nav1p1 ", vhminf_nav1p1 
print   "kminf_nav1p1 ", kminf_nav1p1
    
print    "amtaul_nav1p1 ", amtaul_nav1p1
print    "bmtaul_nav1p1 ", bmtaul_nav1p1
print    "cmtaul_nav1p1 ", cmtaul_nav1p1 
print    "dmtaul_nav1p1 ", dmtaul_nav1p1

print    "brkvmtau_nav1p1 ", brkvmtau_nav1p1
    
print    "amtaur_nav1p1 ", amtaur_nav1p1
print    "bmtaur_nav1p1 ", bmtaur_nav1p1
print    "cmtaur_nav1p1 ", cmtaur_nav1p1
print    "dmtaur_nav1p1 ", dmtaur_nav1p1 

print    "vhhinf_nav1p1 ", vhhinf_nav1p1
print    "khinf_nav1p1 ", khinf_nav1p1
    
print    "ahtaul_nav1p1 ", ahtaul_nav1p1
print    "bhtaul_nav1p1 ", bhtaul_nav1p1
print    "chtaul_nav1p1 ", chtaul_nav1p1
print    "dhtaul_nav1p1 ", dhtaul_nav1p1

print    "brkvhtau_nav1p1 ", brkvhtau_nav1p1
    
print    "ahtaur_nav1p1 ", ahtaur_nav1p1
print    "bhtaur_nav1p1 ", bhtaur_nav1p1 
print    "chtaur_nav1p1 ", chtaur_nav1p1 
print    "dhtaur_nav1p1 ", dhtaur_nav1p1
print    "gnabar_nav1p1 ", gnabar_nav1p1
}

proc nav1p6param(){         
print   "vhminf_nav1p6 ", vhminf_nav1p6 
print   "kminf_nav1p6 ", kminf_nav1p6
    
print    "amtaul_nav1p6 ", amtaul_nav1p6
print    "bmtaul_nav1p6 ", bmtaul_nav1p6
print    "cmtaul_nav1p6 ", cmtaul_nav1p6 
print    "dmtaul_nav1p6 ", dmtaul_nav1p6

print    "brkvmtau_nav1p6 ", brkvmtau_nav1p6
    
print    "amtaur_nav1p6 ", amtaur_nav1p6
print    "bmtaur_nav1p6 ", bmtaur_nav1p6
print    "cmtaur_nav1p6 ", cmtaur_nav1p6
print    "dmtaur_nav1p6 ", dmtaur_nav1p6 

print    "vhhinf_nav1p6 ", vhhinf_nav1p6
print    "khinf_nav1p6 ", khinf_nav1p6
    
print    "ahtaul_nav1p6 ", ahtaul_nav1p6
print    "bhtaul_nav1p6 ", bhtaul_nav1p6
print    "chtaul_nav1p6 ", chtaul_nav1p6
print    "dhtaul_nav1p6 ", dhtaul_nav1p6

print    "brkvhtau_nav1p6 ", brkvhtau_nav1p6
    
print    "ahtaur_nav1p6 ", ahtaur_nav1p6
print    "bhtaur_nav1p6 ", bhtaur_nav1p6 
print    "chtaur_nav1p6 ", chtaur_nav1p6 
print    "dhtaur_nav1p6 ", dhtaur_nav1p6
print    "gnabar_nav1p6 ", gnabar_nav1p6
}


proc nav1p7param(){     
print   "vhminf_nav1p7 ", vhminf_nav1p7 
print   "kminf_nav1p7 ", kminf_nav1p7
    
print    "amtaul_nav1p7 ", amtaul_nav1p7
print    "bmtaul_nav1p7 ", bmtaul_nav1p7
print    "cmtaul_nav1p7 ", cmtaul_nav1p7 
print    "dmtaul_nav1p7 ", dmtaul_nav1p7

print    "brkvmtau_nav1p7 ", brkvmtau_nav1p7
    
print    "amtaur_nav1p7 ", amtaur_nav1p7
print    "bmtaur_nav1p7 ", bmtaur_nav1p7
print    "cmtaur_nav1p7 ", cmtaur_nav1p7
print    "dmtaur_nav1p7 ", dmtaur_nav1p7 
    
print    "vhhinf_nav1p7 ", vhhinf_nav1p7
print    "khinf_nav1p7 ", khinf_nav1p7
    
print    "ahtaul_nav1p7 ", ahtaul_nav1p7
print    "bhtaul_nav1p7 ", bhtaul_nav1p7
print    "chtaul_nav1p7 ", chtaul_nav1p7
print    "dhtaul_nav1p7 ", dhtaul_nav1p7

print    "brkvhtau_nav1p7 ", brkvhtau_nav1p7
    
print    "ahtaur_nav1p7 ", ahtaur_nav1p7
print    "bhtaur_nav1p7 ", bhtaur_nav1p7 
print    "chtaur_nav1p7 ", chtaur_nav1p7 
print    "dhtaur_nav1p7", dhtaur_nav1p7
print    "gnabar_nav1p7 ", gnabar_nav1p7
}

proc nav1p8param(){         
print   "vhminf_nav1p8 ", vhminf_nav1p8 
print   "kminf_nav1p8 ", kminf_nav1p8
    
print    "amtaul_nav1p8 ", amtaul_nav1p8
print    "bmtaul_nav1p8 ", bmtaul_nav1p8
print    "cmtaul_nav1p8 ", cmtaul_nav1p8 
print    "dmtaul_nav1p8 ", dmtaul_nav1p8

print    "brkvmtau_nav1p8 ", brkvmtau_nav1p8
    
print    "amtaur_nav1p8 ", amtaur_nav1p8
print    "bmtaur_nav1p8 ", bmtaur_nav1p8
print    "cmtaur_nav1p8 ", cmtaur_nav1p8
print    "dmtaur_nav1p8 ", dmtaur_nav1p8 

print    "vhhinf_nav1p8 ", vhhinf_nav1p8
print    "khinf_nav1p8 ", khinf_nav1p8
    
print    "ahtaul_nav1p8 ", ahtaul_nav1p8
print    "bhtaul_nav1p8 ", bhtaul_nav1p8
print    "chtaul_nav1p8 ", chtaul_nav1p8
print    "dhtaul_nav1p8 ", dhtaul_nav1p8

print    "brkvhtau_nav1p8 ", brkvhtau_nav1p8
    
print    "ahtaur_nav1p8 ", ahtaur_nav1p8
print    "bhtaur_nav1p8 ", bhtaur_nav1p8 
print    "chtaur_nav1p8 ", chtaur_nav1p8 
print    "dhtaur_nav1p8 ", dhtaur_nav1p8
print    "gnabar_nav1p8 ", gnabar_nav1p8
}

proc kv1param(){
print   "vhninf_kv1 ", vhninf_kv1 
print   "kninf_kv1 ", kninf_kv1
    
print    "antaul_kv1 ", antaul_kv1
print    "bntaul_kv1 ", bntaul_kv1
print    "cntaul_kv1 ", cntaul_kv1 
print    "dntaul_kv1 ", dntaul_kv1

print    "brkvntau_kv1 ", brkvntau_kv1
    
print    "antaur_kv1 ", antaur_kv1
print    "bntaur_kv1 ", bntaur_kv1
print    "cntaur_kv1 ", cntaur_kv1
print    "dntaur_kv1 ", dntaur_kv1 

print    "gkbar_kv1 ", gkbar_kv1}


proc kv2param(){
print   "vhninf_kv2 ",vhninf_kv2 
print   "kninf_kv2 ",kninf_kv2
     
print    "antaul_kv2 ",antaul_kv2
print    "bntaul_kv2 ",bntaul_kv2
print    "cntaul_kv2 ",cntaul_kv2 
print    "dntaul_kv2 ",dntaul_kv2

print    "brkvntau_kv2 ", brkvntau_kv2
    
print    "antaur_kv2 ",antaur_kv2
print    "bntaur_kv2 ",bntaur_kv2
print    "cntaur_kv2 ",cntaur_kv2
print    "dntaur_kv2 ",dntaur_kv2 
print    "gkbar_kv2 ", gkbar_kv2
}

proc kv3param(){
print   "vhninf_kv3 ",vhninf_kv3 
print   "kninf_kv3 ",kninf_kv3
     
print    "antaul_kv3 ",antaul_kv3
print    "bntaul_kv3 ",bntaul_kv3
print    "cntaul_kv3 ",cntaul_kv3 
print    "dntaul_kv3 ",dntaul_kv3

print    "brkvntau_kv3 ", brkvntau_kv3
    
print    "antaur_kv3 ",antaur_kv3
print    "bntaur_kv3 ",bntaur_kv3
print    "cntaur_kv3 ",cntaur_kv3
print    "dntaur_kv3 ",dntaur_kv3 
print    "gkbar_kv3 ", gkbar_kv3}

proc kv4param(){
print   "vhninf_kv4 ", vhninf_kv4 
print   "kninf_kv4 ", kninf_kv4
    
print    "antaul_kv4 ", antaul_kv4
print    "bntaul_kv4 ", bntaul_kv4
print    "cntaul_kv4 ", cntaul_kv4 
print    "dntaul_kv4 ", dntaul_kv4

print    "brkvntau_kv4 ", brkvntau_kv4
    
print    "antaur_kv4 ", antaur_kv4
print    "bntaur_kv4 ", bntaur_kv4
print    "cntaur_kv4 ", cntaur_kv4
print    "dntaur_kv4 ", dntaur_kv4 
    
print    "vhhinf_kv4 ", vhhinf_kv4
print    "khinf_kv4 ", khinf_kv4
    
print    "ahtaul_kv4 ", ahtaul_kv4
print    "bhtaul_kv4 ", bhtaul_kv4
print    "chtaul_kv4 ", chtaul_kv4
print    "dhtaul_kv4 ", dhtaul_kv4

print    "brkvhtau_kv4 ", brkvhtau_kv4
    
print    "ahtaur_kv4 ", ahtaur_kv4
print    "bhtaur_kv4 ", bhtaur_kv4 
print    "chtaur_kv4 ", chtaur_kv4 
print    "dhtaur_kv4 ", dhtaur_kv4
print    "gkbar_kv4 ", gkbar_kv4}


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