Olfactory Bulb Network (Davison et al 2003)

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Accession:2730
A biologically-detailed model of the mammalian olfactory bulb, incorporating the mitral and granule cells and the dendrodendritic synapses between them. The results of simulation experiments with electrical stimulation agree closely in most details with published experimental data. The model predicts that the time course of dendrodendritic inhibition is dependent on the network connectivity as well as on the intrinsic parameters of the synapses. In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization. For more details, see the reference below.
Reference:
1 . Davison AP, Feng J, Brown D (2003) Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model. J Neurophysiol 90:1921-35 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Synchronization; Spatio-temporal Activity Patterns; Olfaction;
Implementer(s): Davison, Andrew [Andrew.Davison at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Gaba; Glutamate;
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bulbNet
README *
cadecay.mod *
flushf.mod *
kA.mod *
kca.mod *
kfasttab.mod *
kM.mod *
kslowtab.mod *
lcafixed.mod *
nafast.mod *
nagran.mod *
nmdanet.mod *
bulb.hoc
calcisilag.hoc *
ddi_baseline.gnu *
ddi_baseline.ses *
experiment_ddi_baseline.hoc *
experiment_odour_baseline.hoc *
granule.tem *
init.hoc *
input.hoc *
input1 *
mathslib.hoc *
mitral.tem *
mosinit.hoc *
odour_baseline.connect
odour_baseline.gnu *
odour_baseline.ses *
parameters_ddi_baseline.hoc *
parameters_odour_baseline.hoc *
screenshot.png *
tabchannels.dat *
tabchannels.hoc *
                            
# gnuplot file to produce a figure similar to Figure 8
# in Davison A.P., Feng J. and Brown D. (2003) J. Neurophysiol.

# Note that the figure produced will not match exactly the
# published figure due to differences in the sequence of
# random numbers used to set up the network.

# gnuplot is available from http://www.gnuplot.info

set term postscript portrait enhanced mono solid "Helvetica" 8
set output "odour_baseline.eps"

set size 0.49,0.5
set multiplot

set size 0.445,0.115
set tmargin 0
set bmargin 0
set lmargin 0
set rmargin 0
set noxtics
set noytics
set nokey

set noborder
set origin 0,0.375
set label 1 '{/Helvetica=14 A}' at screen 0.01,0.475
plot [0:3000][-0.5:35.5] "odour_baseline.ras" using 4:3 with points pointtype 7 pointsize 0.3

set origin 0,0.25
set label 1 '{/Helvetica=14 B}' at screen 0.01,0.35
set border 1 linewidth 0.5
plot [0:3000] "odour_baseline.smhist" with lines linewidth 0.5

set origin 0,0.125
set noborder
set label 1 '{/Helvetica-Bold=14 C}' at screen 0.01,0.225
plot [0:3000] "odour_baseline.gran.ras" using 4:3 with dots

set origin 0,0.0
set border 1 linewidth 0.5
set label 1 '{/Helvetica-Bold=14 D}' at screen 0.01,0.10
set arrow from 200,70 to 700,70 nohead linewidth 2
set label 2 '500 ms' at 250,55
plot [0:3000] "odour_baseline.gran.smhist" with lines linewidth 0.5

set size 0.05,0.115
set origin 0.45,0.375
set nolabel 1
set border 2 lw 0.5
set noarrow
#plot "input1.nbar" using 1:($2+1) with steps linetype 2 linewidth 0.5
set arrow from 5,-1.5 to 25,-1.5 nohead lw 2
set label 2 '{/=8 10 s^{/=6 -1}}' at -1,-5
#plot [0:34][] "odour_baseline.nbar" using 1:($2+1.1) with steps linewidth 0.5

set origin 0.45,0.125
set noarrow
set nolabel
#plot [0:34][] "odour_baseline2.gran.nbar" using 1:($2+1) with steps linewidth 0.2

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