ModelDB: Olfactory Bulb Network (Davison et al 2003)

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Olfactory Bulb Network (Davison et al 2003)

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Accession:2730

A biologically-detailed model of the mammalian olfactory bulb, incorporating the mitral and granule cells and the dendrodendritic synapses between them. The results of simulation experiments with electrical stimulation agree closely in most details with published experimental data. The model predicts that the time course of dendrodendritic inhibition is dependent on the network connectivity as well as on the intrinsic parameters of the synapses. In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization. For more details, see the reference below.
Reference:
1 . Davison AP, Feng J, Brown D (2003) Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model. J Neurophysiol 90:1921-35 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network;
Brain Region(s)/Organism:	Olfactory bulb;
Cell Type(s):	Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s):	I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):	GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Oscillations; Synchronization; Spatio-temporal Activity Patterns; Olfaction;
Implementer(s):	Davison, Andrew [Andrew.Davison at iaf.cnrs-gif.fr];