CA1 Pyramidal Neuron: slow Na+ inactivation (Migliore 1996)

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Accession:2937
Model files from the paper: M. Migliore, Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons, Biophys. J. 71:2394-403 (1996). Please see the below readme file for installation and use instructions. Contact michele.migliore@pa.ibf.cnr.it if you have any questions about the implementation of the model.
Reference:
1 . Migliore M (1996) Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons. Biophys J 71:2394-403 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I K; I M; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Synaptic Integration;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,t; I K; I M; I h;
{NumSoma=1 NumApical=13 NumBasal=3 NumAxon=1}
create soma[NumSoma], apical[NumApical], basal[NumBasal],axon[NumAxon]

axon[0]  {nseg=5 diam=2 L=50}
soma[0]  {nseg=1 diam= 10  L= 15  }

apical[0]   {nseg=4 diam= 4  L= 100  }
apical[1]   {nseg=4 diam= 3  L= 100  }
apical[2]   {nseg=5 diam= 3  L= 150  }
apical[3]   {nseg=2 diam= 2  L= 90  }
apical[4]   {nseg=10 diam= 0.7  L= 200  }
apical[5]   {nseg=3 diam= 1.5  L= 90  }
apical[6]   {nseg=10 diam= 0.7  L= 200  }
apical[7]   {nseg=3 diam= 1.9  L= 90 }
apical[8]   {nseg=8 diam= 0.7  L= 200  }
apical[9]   {nseg=8 diam= 0.7  L= 200  }
apical[10]   {nseg=3 diam= 1.9  L= 90  }
apical[11]   {nseg=8 diam= 0.7  L= 200  }
apical[12]   {nseg=8 diam= 0.7  L= 200  }

basal[0]  {nseg=4 diam= 1.5  L= 100  }
basal[1]  {nseg=6 diam= 1.5  L= 150  }
basal[2]  {nseg=4 diam= 2  L= 100  }

soma[0]  {  connect apical[0] (0),1
         connect basal[0] (0),0
	 connect basal[1] (0),0
	 connect basal[2] (0),0
	 connect axon[0](0),0.5}

apical[0]  {connect apical[ 1]  (0), 1
connect apical[3]  (0), 1}
apical[1]  {connect apical[ 2]  (0), 1
connect apical[5]  (0), 1}
apical[2]  {connect apical[ 7]  (0), 1
connect apical[10]  (0), 1}
apical[3]  {connect apical[ 4]  (0), 1}
apical[5]  {connect apical[ 6]  (0), 1}
apical[7]  {connect apical[ 8]  (0), 1}
apical[8]  {connect apical[ 9]  (0), 1}
apical[10]  {connect apical[ 11]  (0), 1}
apical[11]  {connect apical[ 12]  (0), 1}



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