Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
/*
To simulate the electrode we add a small section to
serve as the electrode resistance and capacitance
*/

/*
watch out when changing Ra in the model since this
electrode.Ra is used for the series resistance!
*/

begintemplate Electrode

public electrode
create electrode

// c (pf) = cm*area = PI*L*diam*(.01) * cm
// rs (MOhm) = Ra*L/2 / (PI*diam^2/4) = 2*L/PI/diam^2 * (.01) * Ra

// so it is nice to have
// PI*L*diam*.01 = 1
// 2*L/PI/diam^2*.01 = 1

// diam = (2/PI^2)^(1/3)
// L = 1/.01/PI/diam


proc init_electrode() {
	electrode {
		diam = (2/PI^2)^(1/3)
		L = 1/.01/PI/diam
		insert pas
		g_pas = 0
		e_pas = 0
	}
}

proc init() {
        init_electrode()
        electrode Ra = 0.001		//(Ohm*cm)
        electrode cm = 0		//(uF/cm2)
        connect electrode(0), $1
}



//electrode makeppm()

endtemplate Electrode

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