Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
load_file("nrngui.hoc")
load_file("init.hoc")
load_file(1, "fig3a.ses")
doNotify()

for i=0, 1 {
        InhiSyn[i].gmaxampa = 0
        InhiSyn[i].gmaxnmda = 0
}
hoc_ac_ = .5
tuftden[1] PointProcessManager[1].move()
hoc_ac_ = .5
tuftden[0] PointProcessManager[2].move()
GluSyn[0].onset = 2
GluSyn[1].onset = 2
tstop = 15

proc grun() {local i
	for i=0, 1 {
		GluSyn[i].gmaxampa = $1
		GluSyn[i].gmaxnmda = $1*.5
	}
        run()
}

xpanel("GluSyn Strength Run")
xbutton("3(nS)", "grun(.003)")
xbutton("6.5(nS)", "grun(.0065)")
xbutton("7(nS)", "grun(.007)")
xpanel(100, 400)


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