Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
load_file("init.hoc")
load_file(1, "fig5a.ses")
Graph[0].exec_menu("Keep Lines")
proc irun() {
	for i=0,1 GluSyn[i].onset=$1
	for i=0,1 {GluSyn[i].gmaxampa=$2 GluSyn[i].gmaxnmda=$2*.5}
	for i=0,1 {InhiSyn[i].gmaxampa = 0 InhiSyn[i].gmaxnmda = $3}
	run()
}

hoc_ac_ = .5
tuftden[1] PointProcessManager[1].move()
hoc_ac_ = .5
tuftden[0] PointProcessManager[2].move()

jjj=0
for case(&jjj, 40, 30, 50, 60, 70, 20) {
	irun(jjj, 0.01, .12)
	if (stoprun) break
}

if (!stoprun) {
	irun(10, .01, 0)
}

Graph[0].exec_menu("Keep Lines")


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