Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
load_file("init.hoc")
load_file(1, "fig5b.ses")

hoc_ac_ = .5
tuftden[1] PointProcessManager[1].move()
hoc_ac_ = .5
tuftden[0] PointProcessManager[2].move()

for i=0,1 GluSyn[i].onset=40
for i=0,1 {GluSyn[i].gmaxampa = 0.01 GluSyn[i].gmaxnmda = 0.005}
for i=0,1 {InhiSyn[i].gmaxampa = 0 InhiSyn[i].gmaxnmda = 0.12}
tstop=41

objref stopvec
stopvec=new Vector()
stopvec.append(41.5, 42, 42.3, 42.5, 42.9, 43.1, 43.3, 43.4, 43.5, 43.6,\
                 43.9, 44.2, 44.4, 44.7)

proc fig5binit() {local i
	for i=1,2 { Graph[i].erase() }
	stdrun_quiet=1
	stdinit()
	continuerun(41)
	stdrun_quiet=0
	stopindex = 0	
}

func fig5step() {
	if (stopindex < stopvec.size) {
		continuerun(stopvec.x[stopindex])
		stopindex += 1
		return 1
	}
	return 0
}

fig5binit()
while(fig5step()) {
	Graph[0].mark(t, priden.v(.75), "O", 6, 3, 1)
	for i=1,2 Graph[i].exec_menu("Keep Lines")
	for i=1,2 Graph[i].exec_menu("Keep Lines")
}

/* inside fig5b.ses
xpanel("Start over")
xbutton("Re-initialize", "fig5binit()")
xbutton("SingleStep", "fig5step()")
xpanel()
*/

Loading data, please wait...