Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
load_file("init.hoc")
load_file(1, "fig6.ses")

hoc_ac_ = .5
tuftden[1] PointProcessManager[1].move()
hoc_ac_ = .5
tuftden[0] PointProcessManager[2].move()

for i=0,1 GluSyn[i].onset=40
for i=0,1 {GluSyn[i].gmaxampa = 0.01 GluSyn[i].gmaxnmda = 0.005}
for i=0,1 {InhiSyn[i].gmaxampa = 0 InhiSyn[i].gmaxnmda = 0.12}

tstop=41

proc fig6ginit() {
	priden.gbar_na = soma.gbar_na
	priden.gbar_kd = soma.gbar_kd
	priden.g_pas = soma.g_pas
	priden.e_pas = soma.e_pas
}

proc fig6init() {local i
	fig6ginit()
	stdrun_quiet=1
	stdinit()
	if (!stoprun) continuerun(41)
	stdrun_quiet=0
	if (!stoprun) continuerun(43.4)
}

//control
fig6init()
if (!stoprun) continuerun(47)
Graph[0].exec_menu("Keep Lines")

//eliminate sodium
fig6init()
priden.gbar_na = 0
if(!stoprun)continuerun(47)

// eliminate sodium and potasium
fig6init()
priden.gbar_na = 0
priden.gbar_kd = 0
if(!stoprun)continuerun(47)

// freeze the conductance
fig6init()
priden.gbar_na = 0
priden.gbar_kd = 0
priden for (x) if (x > 0 && x < 1) {
	gp = g_pas(x)
	g = gp + 1e-4*gna_na(x) + 1e-4*gk_kd(x)
	g_pas(x) = g
	e_pas(x) = (gp*e_pas(x) + 1e-4*gna_na(x)*ena(x) + 1e-4*gk_kd(x)*ek(x))/g
}
if(!stoprun)continuerun(47)

fig6ginit()


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