Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
objref glu[6]
j=0
for i=0,1 tuftden[i] for (x) if (x > 0 && x < 1) {glu[j] = new GluSyn(x) j+=1}
for i=0,5 {
	glu[i].onset = 2
	glu[i].tp = 1.5
	glu[i].tau1 = 80
	glu[i].tau2 = 5
}
for i=0,1 {GluSyn[i].gmaxampa = 0 GluSyn[i].gmaxnmda=0}

proc grun() {local i
	for i=0, 5 {
		glu[i].gmaxampa = $1/3
		glu[i].gmaxnmda = $1*.5/3
	}
        run()
}

proc irun() {local i
	for i=0, 5 {
		glu[i].onset = $1
		glu[i].gmaxampa = $2/3
		glu[i].gmaxnmda = $2*.5/3
	}
        for i=0,1 {InhiSyn[i].gmaxampa = 0 InhiSyn[i].gmaxnmda = $3}
        run()
}


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