Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
// beginning of two electrode mitral cell simulations
xopen("$(NEURONHOME)/lib/hoc/noload.hoc")
xopen("mitral.hoc")
xopen("memb.hoc")
//xopen("electrode.hoc")
xopen("param.hoc")
xopen("syns.ses")
proc init() {local dtsav, i, act
	act = cvode.active()
        finitialize(v_init)
	cvode_active(0)
        fcurrent()
        forsec sad for(x) if (x>=0 && x<=1) {
		e_pas(x) = (ina(x) + ik(x) + g_pas(x)*v_init)/g_pas(x)
	} 
        t = -200
        dtsav = dt
        dt = 10
        for i = 0, 19 {
        	fadvance()
        }
        dt = dtsav
        t = 0
	fcurrent()
	if (act) {
		cvode_active(act)
		cvode.re_init()
	}
}
tstop=80


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