Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
// High and low current stimulus into soma and primary electrodes
// soma and primary electrode voltage recorded for each of these
// four protocols
// original data filenames are
// 970310.034.5,9 (soma high and low current injection)
// 970310.033.2,7 (primary high and low current injection)
// and are exactly the same as the shen1999 data in the files
// data/3459.dat and data/3327.dat

load_file("nrngui.hoc")
load_file("init.hoc")
load_file("electrode.hoc")

objref se, pe, te // so it can be restarted, we declare them here
soma se=new Electrode(0.5)
priden {pe=new Electrode(0.7)}


se.electrode.Ra = 0.001
se.electrode.cm = 0
pe.electrode.Ra = 15
pe.electrode.cm = 2.95

objref pestim, sestim
pe.electrode pestim = new IClamp(.5)
se.electrode sestim = new IClamp(.5)
pestim.del = 1
pestim.dur = 10
sestim.del = 1
sestim.dur = 10

load_file(1, "istimfit.ses")
doNotify()

for i=0, 1 {
        InhiSyn[i].gmaxampa = 0
        InhiSyn[i].gmaxnmda = 0
	GluSyn[i].gmaxampa = 0
	GluSyn[i].gmaxnmda= 0
}

// anatomy and channel density for this data

forsec tuft diam = 2
priden.L = 330
connect pe.electrode(0), priden(0.75)
hillock.L = 10
initialseg.L = 20
initialseg.diam = 1.2

initialseg.gbar_na = 10000
forsec somden gbar_na = 250


tstop = 20

object_push(MulRunFitter[0].p)
gview()
doNotify()
runall()
object_pop()


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