Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
//Wei's two electrodes expriments show active channels in the
//distal portion  of the primary dendrite. This set up a hotspot there.
//using Zachs na and k channels with density similarities to his paper

proc memb() {
	forall {insert pas}
	forall {insert na  insert kd}

	celsius = 23
	set_ra(70)

	forall {
		cm = 1.2
		g_pas = 1/30000
		e_pas = -65
		ek = -90
		ena = 60
	}

	forsec "myelin" {
		cm = 0.012
		g_pas = 1/100000
		gbar_na = 0
		gbar_kd = 0
	}
	
	forsec "node" {
	        g_pas = 1/1000
	        gbar_na = 30000
	        gbar_kd = 500
	}
	
	initialseg {
	        g_pas = 1/1000
	        gbar_na = 30000
	        gbar_kd = 500
	}       
}

memb()


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