Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
// particular geometrical values for double spike simulation
priden { L = 300  diam = 3.2 }
initialseg{ L=30  diam=1.5}
forsec tuft diam=1.8
hillock.L = 5

forsec sad cm = 1
forsec "myelin" cm=0.01
thm1_na = -73.1718
thm2_na = -20.885
Am1_na = 0.174565
Am2_na = 0.710094
qm1_na = 4.35318
qm2_na = 6.51715
thi1_na = -32.0296
thi2_na = -78.4418
qi_na = 2.0038
thinf_na = -38.8877
qinf_na = 10.9109
Rg_na = 2.99989
Rd_na = 0.0931745
Ra_kd = 0.596458
Rb_kd = 0.0128992
tha_kd = 1.00846
qa_kd = 13.5709
forsec somden Ra = 70
forsec "node" gbar_na = 5000 //too high a density can cause repolarization failure
forsec "node" gbar_kd = 100
initialseg.gbar_na = 20000
initialseg.gbar_kd = 100
forsec somden gbar_na = 175
forsec somden gbar_kd = 50.6382


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