Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

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Accession:3793
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference:
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;
load_file("nrngui.hoc")
objectvar save_window_, rvp_
objectvar scene_vector_[6]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
secden[1] ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("AlphaSynapse") i = mt.selected()
ms[i] = new MechanismStandard("AlphaSynapse")
ms[i].set("onset", 1, 0)
ms[i].set("tau", 15, 0)
ms[i].set("gmax", 0, 0)
ms[i].set("e", -75, 0)
mt.select("InhiSyn") i = mt.selected()
ms[i] = new MechanismStandard("InhiSyn")
ms[i].set("onset", 1, 0)
ms[i].set("tp", 5, 0)
ms[i].set("gmaxampa", 0.2, 0)
ms[i].set("tau1", 80, 0)
ms[i].set("tau2", 3, 0)
ms[i].set("gmaxnmda", 0.135, 0)
ms[i].set("erev", -70, 0)
mt.select("InhiSyn") i = mt.selected() maction(i)
hoc_ac_ = 0.1
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 827, 480, 277.44, 400.32)
}
objref ocbox_
//End PointProcessManager

{WindowMenu[0].ses_gid(1, 0, 0, "Synapses")}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
tuftden[1] ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("GluSyn") i = mt.selected()
ms[i] = new MechanismStandard("GluSyn")
ms[i].set("onset", 40, 0)
ms[i].set("tp", 1.5, 0)
ms[i].set("gmaxampa", 0.007, 0)
ms[i].set("tau1", 80, 0)
ms[i].set("tau2", 5, 0)
ms[i].set("gmaxnmda", 0.04, 0)
ms[i].set("erev", 0, 0)
mt.select("GluSyn") i = mt.selected() maction(i)
hoc_ac_ = 0.166667
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 524, 478, 277.44, 400.32)
}
objref ocbox_
//End PointProcessManager

{WindowMenu[0].ses_gid(0, 0, 0, "Synapses")}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
tuftden[0] ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("GluSyn") i = mt.selected()
ms[i] = new MechanismStandard("GluSyn")
ms[i].set("onset", 40, 0)
ms[i].set("tp", 1.5, 0)
ms[i].set("gmaxampa", 0.007, 0)
ms[i].set("tau1", 80, 0)
ms[i].set("tau2", 5, 0)
ms[i].set("gmaxnmda", 0.04, 0)
ms[i].set("erev", 0, 0)
mt.select("GluSyn") i = mt.selected() maction(i)
hoc_ac_ = 0.166667
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 516, 28, 277.44, 400.32)
}
objref ocbox_
//End PointProcessManager

{WindowMenu[0].ses_gid(0, 0, 0, "Synapses")}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
secden[0] ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("InhiSyn") i = mt.selected()
ms[i] = new MechanismStandard("InhiSyn")
ms[i].set("onset", 1, 0)
ms[i].set("tp", 5, 0)
ms[i].set("gmaxampa", 0.2, 0)
ms[i].set("tau1", 80, 0)
ms[i].set("tau2", 3, 0)
ms[i].set("gmaxnmda", 0.135, 0)
ms[i].set("erev", -70, 0)
mt.select("InhiSyn") i = mt.selected() maction(i)
hoc_ac_ = 0.1
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 823, 29, 277.44, 400.32)
}
objref ocbox_
//End PointProcessManager

{WindowMenu[0].ses_gid(0, 0, 0, "Synapses")}
{
xpanel("RunControl", 0)
v_init = -65
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 40
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 0.1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 0
xvalue("t","t", 2 )
tstop = 80
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.025
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 40
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 0
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(78,102)
}
objectvar scene_vector_[1]
{doNotify()}

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