Spinal Motor Neuron (Dodge, Cooley 1973)

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Accession:3805
"The excitability of various regions of the spinal motorneuron can be specified by solving the partial differential equation of a nerve fiber whose diameter and membrane properties vary with distance. For our model geometrical factors for the myelinated axon, initial segment and cell body were derived from anatomical measurements, the dendritic tree was represented by its equivalent cylinder, and the current-voltage relations of the membrane were described by a modification of the Hodgkin-Huxley model that fits voltage-clamp data from the motorneuron. ..."
Reference:
1 . Dodge FA, Cooley JW (1973) Action Potential of the Motorneuron. IBM J Res Dev 17:219-29
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Active Dendrites; Tutorial/Teaching; Axonal Action Potentials; Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,t; I K;
load_file("nrngui.hoc")
objectvar save_window_, rvp_
objectvar scene_vector_[5]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
soma ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("SEClamp") i = mt.selected()
ms[i] = new MechanismStandard("SEClamp")
ms[i].set("rs", 0.0001, 0)
ms[i].set("dur1", 1, 0)
ms[i].set("amp1", 120, 0)
ms[i].set("dur2", 0, 0)
ms[i].set("amp2", 0, 0)
ms[i].set("dur3", 0, 0)
ms[i].set("amp3", 0, 0)
mt.select("SEClamp") i = mt.selected() maction(i)
hoc_ac_ = 0.5
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 47, 509, 320.64, 460.8)
}
objref ocbox_
//End PointProcessManager


//Begin Insert/Remove Mechanisms
{
load_file("inserter.hoc", "Inserter")
}
{
soma ocbox_ = new Inserter(0)
}
{object_push(ocbox_)}
{
mt.select("dc") i = mt.selected()
ms[i] = new MechanismStandard("dc")
ms[i].set("gnabar_dc", 0.07, 0)
ms[i].set("gkbar_dc", 0.0175, 0)
ms[i].set("gl_dc", 0.00167, 0)
ms[i].set("el_dc", 0, 0)
ms[i].set("shift_dc", 0, 0)
mstate[i]= 1
maction(i)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("Insert/Remove Mechanisms", 397, 34, 91.2, 111.36)
}
objref ocbox_
//End Insert/Remove Mechanisms

{
xpanel("RunControl", 0)
v_init = 0
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 1
xvalue("t","t", 2 )
tstop = 1
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.002
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 500
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 0
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(88,113)
}
{
save_window_ = new Graph(0)
save_window_.size(-4.47035e-08,1.5,0,120)
scene_vector_[3] = save_window_
{save_window_.view(-4.47035e-08, 0, 1.5, 120, 393, 183, 301.44, 103.36)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
{
xpanel("soma(0 - 1) (Parameters)", 0)
xlabel("soma(0 - 1) (Parameters)")
xlabel("nseg = 1")
soma.L = 60
xvalue("L","soma.L", 1,"define_shape()", 0, 0 )
soma.diam = 300
xvalue("diam","soma.diam", 1,"", 0, 0 )
soma.cm = 1
xvalue("cm","soma.cm", 1,"", 0, 0 )
soma.gnabar_dc = 0.07
xvalue("gnabar_dc","soma.gnabar_dc", 1,"", 0, 0 )
soma.gkbar_dc = 0.0175
xvalue("gkbar_dc","soma.gkbar_dc", 1,"", 0, 0 )
soma.gl_dc = 0.00167
xvalue("gl_dc","soma.gl_dc", 1,"", 0, 0 )
soma.el_dc = 0
xvalue("el_dc","soma.el_dc", 1,"", 0, 0 )
soma.shift_dc = 0
xvalue("shift_dc","soma.shift_dc", 1,"", 0, 0 )
soma.ena = 115
xvalue("ena","soma.ena", 1,"", 0, 0 )
soma.ek = -5
xvalue("ek","soma.ek", 1,"", 0, 0 )
xpanel(727,33)
}
{
save_window_ = new Graph(0)
save_window_.size(-2.98023e-08,1.5,-1000,1000)
scene_vector_[4] = save_window_
{save_window_.view(-2.98023e-08, -1000, 1.5, 2000, 396, 352, 299.52, 306.88)}
graphList[1].append(save_window_)
save_window_.save_name("graphList[1].")
save_window_.addvar("SEClamp[0].i", 1, 1, 0.476282, 0.962565, 2)
}

//Begin special
{
load_file("family.hoc", "Family")
}
{
ocbox_ = new Family(0)
}
{object_push(ocbox_)}
{
xstart=30  xend=120  nstep=7  setval() build()

variable = "SEClamp[0].amp1"
generator = "run()"
}
{object_pop()}
{
ocbox_ = ocbox_.box
ocbox_.map("special", 398, 732, 242.88, 250.56)
}
objref ocbox_
//End special

objectvar scene_vector_[1]
{doNotify()}

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