Spinal Motor Neuron (Dodge, Cooley 1973)

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"The excitability of various regions of the spinal motorneuron can be specified by solving the partial differential equation of a nerve fiber whose diameter and membrane properties vary with distance. For our model geometrical factors for the myelinated axon, initial segment and cell body were derived from anatomical measurements, the dendritic tree was represented by its equivalent cylinder, and the current-voltage relations of the membrane were described by a modification of the Hodgkin-Huxley model that fits voltage-clamp data from the motorneuron. ..."
1 . Dodge FA, Cooley JW (1973) Action Potential of the Motorneuron. IBM J Res Dev 17:219-29
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Active Dendrites; Tutorial/Teaching; Axonal Action Potentials; Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,t; I K;
forall insert extracellular // so we can plot i_membrane
load_file(1, "fig7.ses")

hyper =  -18

proc init() {local a1, a2, ic, savdt, i
	//steady state at specific soma potential then switch to
	//steady current injection
	a1 = IClamp[0].amp  IClamp[0].amp = 0
	IClamp[1].amp = 0
	OClamp[0].vc = -hyper
	OClamp[0].switched_on = 1
	savdt = dt
	dt = 100
	for i=0, 10 {fadvance()}
	ic = OClamp[0].i

	dt = savdt
	OClamp[0].switched_on = 0
	IClamp[0].amp = a1
	IClamp[1].amp = ic

Graph[0].exec_menu("Keep Lines")
// with this simulation a final value of 36 allows the is to spike
for case(&hyper, 0, 9, 13.5, 18, 27, 38) {
Graph[0].exec_menu("Keep Lines")

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