Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)

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Accession:3817
This package shows single-compartment models of different classes of cortical neurons, such as the "regular-spiking", "fast-spiking" and "bursting" (LTS) neurons. The mechanisms included are the Na+ and K+ currents for generating action potentials (INa, IKd), the T-type calcium current (ICaT), and a slow voltage-dependent K+ current (IM). See http://cns.fmed.ulaval.ca/alain_demos.html
References:
1 . Destexhe A, Contreras D, Steriade M (1998) Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells. J Neurophysiol 79:999-1016 [PubMed]
2 . Destexhe A, Contreras D, Steriade M (2001) LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38:555-563
3 . Destexhe A, Sejnowski TJ (2001) Thalamocortical Assemblies-How Ion Channels, Single Neurons and large-Scale Networks Organize Sleep
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex L5/6 pyramidal GLU cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I Na,t; I T low threshold; I K; I M; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Action Potentials; Calcium dynamics;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex L5/6 pyramidal GLU cell; GabaA; GabaB; AMPA; Gaba; I Na,t; I T low threshold; I K; I M; I Sodium; I Calcium; I Potassium;
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cortex
README *
cadecay.mod *
hh2.mod *
IM.mod *
IT.mod *
demo_IN_FS.oc *
demo_PY_LTS.oc *
demo_PY_RS.oc *
mosinit.hoc *
rundemo.hoc *
sIN_template
sPY_template
sPYr_template
                            
//----------------------------------------------------------------------------
//  define a panel to run the different demos
//----------------------------------------------------------------------------

proc make_demopanel() {
	xpanel("Simulations of cortical cells")
	xradiobutton("Regular-spiking pyramidal cell","restart(\"demo_PY_RS\")")
	xradiobutton("Bursting pyramidal cell","restart(\"demo_PY_LTS\")")
        xradiobutton("Fast-spiking interneuronl","restart(\"demo_IN_FS\")")
	xpanel(20,100)
}

proc restart() {local i

//	if (name_declared("IN") == 2) { objref IN[1] }
//	if (name_declared("PY") == 2) { objref PY[1] }
//	if (name_declared("IN") == 2) { objref IN[1] }
//	if (name_declared("El") == 2) { objref El[1] }
	ismenu = 0

	if (electrodes_present) {
		destroy_elec()
	}

	forall delete_section()

	for i=0, n_graph_lists-1 {
		graphList[i].remove_all()
	}
	flush_list.remove_all()
	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
	stoprun = 0
	cvode_active(0)

	ismenu=0
	
	sprint(tstr, "%s.oc", $s1)
	load_file(1, tstr)
}


ismenu=0

load_file("nrngui.hoc")

strdef tstr
ncells=1
objref El[ncells]

electrodes_present=0	// after electrodes are created they must be
			// destroyed if simulation restarted

proc destroy_elec() {
	execute("objref stim, vc",El[0])
}

pwmcnt = PWManager[0].count  // the initial GUIs should not be dismissed

make_demopanel()

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