Spiny neuron model with dopamine-induced bistability (Gruber et al 2003)

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Accession:39949
These files implement a model of dopaminergic modulation of voltage-gated currents (called kir2 and caL in the original paper). See spinycell.html for details of usage and implementation. For questions about this implementation, contact Ted Carnevale (ted.carnevale@yale.edu)
Reference:
1 . Gruber AJ, Solla SA, Surmeier DJ, Houk JC (2003) Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. J Neurophysiol 90:1095-114 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I K,leak; I h; I A, slow;
Gap Junctions:
Receptor(s): D1; Dopaminergic Receptor;
Gene(s): Cav1.3 CACNA1D; D1 DRD1A;
Transmitter(s): Dopamine;
Simulation Environment: NEURON;
Model Concept(s): Intrinsic plasticity;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; D1; Dopaminergic Receptor; I K,leak; I h; I A, slow; Dopamine;
COMMENT
Simple model of synaptic modulation of a second messenger "msg" by dopamine.
msg approaches its steady state msginf with a single time constant tau.
Initially msg has value msginf = 1, and tau is tau0
(default is 100 ms).

If an input event with positive weight w arrives at time t
  If msginf == 1
    msginf = 1+w
    tau = tau1
    send a self-event that will return at t+dur
  else
    move the self-event to t+dur (i.e. just prolong "on" phase)

If a self-event arrives
   msginf = 1
   tau = tau0

An input event with negative weight has no effect.


Affects other mechanisms via POINTER variables linked to msg.


This model has simple dynamics and no stream-specificity.
ENDCOMMENT

NEURON {
	POINT_PROCESS DAsyn
	RANGE tau, tau0, tau1, dur, msg, msginf
}

PARAMETER {
	tau0 = 100 (ms)
	tau1 = 70 (ms)
	dur = 600 (ms)
}

ASSIGNED {
	tau (ms)
	msginf (1)
}

STATE {
	msg (1)
}

INITIAL {
	tau = tau0
	msginf = 1
	msg = 1
}

BREAKPOINT {
	SOLVE state METHOD cnexp
}

DERIVATIVE state {
	msg' = (msginf - msg)/tau
}

NET_RECEIVE (w(1)) {
  if (flag == 0) { : this is an input event
	if (w>0) { : ignore events with nonpositive weight
		if (msginf==1) {
			msginf = 1 + w
			tau = tau1
			net_send(dur, 1)
		} else {
			net_move(t + dur)			
		}
	}
  } else { : this is a self-event
	msginf = 1
	tau = tau0
  }
}

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