Spiny neuron model with dopamine-induced bistability (Gruber et al 2003)

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Accession:39949
These files implement a model of dopaminergic modulation of voltage-gated currents (called kir2 and caL in the original paper). See spinycell.html for details of usage and implementation. For questions about this implementation, contact Ted Carnevale (ted.carnevale@yale.edu)
Reference:
1 . Gruber AJ, Solla SA, Surmeier DJ, Houk JC (2003) Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. J Neurophysiol 90:1095-114 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I K,leak; I h; I A, slow;
Gap Junctions:
Receptor(s): D1; Dopaminergic Receptor;
Gene(s): Cav1.3 CACNA1D; D1 DRD1A;
Transmitter(s): Dopamine;
Simulation Environment: NEURON;
Model Concept(s): Intrinsic plasticity;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; D1; Dopaminergic Receptor; I K,leak; I h; I A, slow; Dopamine;
objectvar save_window_, rvp_
objectvar scene_vector_[9]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}

//Begin NetGUI[0]
{
load_file("netbild.hoc")
}
{ocbox_ = new NetGUI(1)}
{object_push(ocbox_)}
{mapold2new = new Vector()  missing = new List()}
original_type("C")
original_type("Bkgd")
original_type("Stim")
original_type("Stop")
original_type("Reward")
newnode(0, -40, 57)
newnode(1, -88, 57)
newnode(2, 1, 57)
newnode(3, 54, 57)
newnode(4, -42, 12)
newedge(1, 0, 0, 1.05e-05, 1)
newedge(2, 0, 0, 2.4e-06, 1)
newedge(3, 2, 0, -2, 1)
newedge(4, 0, 1, 0.4, 1)
{create_ = 1  create1()}
{g.size(-166.667,166.667,-124.997,124.997)}
{object_pop()}
{
ocbox_.map("NetGUI[0]", 6, 657, 528, 327.36)
}
objref ocbox_
//End NetGUI[0]

objectvar scene_vector_[1]
{doNotify()}

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