Spiny neuron model with dopamine-induced bistability (Gruber et al 2003)

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Accession:39949
These files implement a model of dopaminergic modulation of voltage-gated currents (called kir2 and caL in the original paper). See spinycell.html for details of usage and implementation. For questions about this implementation, contact Ted Carnevale (ted.carnevale@yale.edu)
Reference:
1 . Gruber AJ, Solla SA, Surmeier DJ, Houk JC (2003) Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. J Neurophysiol 90:1095-114 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I K,leak; I h; I A, slow;
Gap Junctions:
Receptor(s): D1; Dopaminergic Receptor;
Gene(s): Cav1.3 CACNA1D; D1 DRD1A;
Transmitter(s): Dopamine;
Simulation Environment: NEURON;
Model Concept(s): Intrinsic plasticity;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; D1; Dopaminergic Receptor; I K,leak; I h; I A, slow; Dopamine;
load_file("nrngui.hoc")
load_file("model_mu_1.ses")  // specifies the biological properties, including the temperature

mu = 1

soma for (x,0) { // skip the nodes at 0 and 1
	setpointer mu_caL(x), mu
	setpointer mu_kir2(x), mu
}


/*
  Model needs a "synaptic conductance" that is tonically activated
  Emulate this with pas
*/

insert pas
e_pas = 0
g_pas = 0


/* Control and Display */

objref g  // for plotting current vs. v

proc newgraph() {
  g = new Graph(0)
  g.size(-90,-30,-1.5,1.5)
  g.view(-90, -1.5, 60, 3, 507, 105, 300.48, 200.32)
  g.label(0.4, 0.9, $s1)
  g.label($s2)
}


/*
  For each desired value of synaptic conductance gs
    Over the specified range of membrane potentials
      Find the steady state total ionic current and append it to a vector
    Plot the vector of ionic current values against the vector of membrane potentials
*/

objref vvec, ivecs, tempvec
vvec = new Vector()
tempvec = new Vector()
ivecs = new List()


proc sweep() { local record_v, tally, i_ionic
  tempvec = new Vector()
  if (vvec.size() == 0) record_v = 1
  for V = -90,-30 {
    if (record_v) vvec.append(V)
    finitialize(V)
    fcurrent()
    tempvec.append(ica + ik + i_leak + i_pas)  // these are all mA/cm2, graphs in paper show uA/cm2
  }
  tempvec.mul(1000)  // convert mA/cm2 to uA/cm2
  tally = ivecs.append(tempvec)
  // plot current vs. v
  ivecs.object(tally-1).plot(g, vvec)
}


gs = 0  // S/cm2

strdef paramstr

proc batchrun() {
  // initialize data storage
  sprint(paramstr, "mu=%g", $2)
  newgraph($s1, paramstr)
  vvec = new Vector()
  ivecs = new List()
  gs = 0
  g_pas = gs
  sweep()
  for case (&gs, 6e-6, 12e-6, 18e-6, 24e-6) {
    g_pas = gs
    sweep()
  }
}

proc fig3B() {
  mu = 1
  batchrun("Fig. 3B", mu)
}

proc fig3C() {
  mu = 1.4
  batchrun("Fig. 3C", mu)
}

proc controlpanel() {
  xpanel("Control",0)
  xbutton("Fig. 3B","fig3B()")
  xbutton("Fig. 3C","fig3C()")
  xpanel(400,105)
}

controlpanel()

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