Spiny neuron model with dopamine-induced bistability (Gruber et al 2003)

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Accession:39949
These files implement a model of dopaminergic modulation of voltage-gated currents (called kir2 and caL in the original paper). See spinycell.html for details of usage and implementation. For questions about this implementation, contact Ted Carnevale (ted.carnevale@yale.edu)
Reference:
1 . Gruber AJ, Solla SA, Surmeier DJ, Houk JC (2003) Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. J Neurophysiol 90:1095-114 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I K,leak; I h; I A, slow;
Gap Junctions:
Receptor(s): D1; Dopaminergic Receptor;
Gene(s): Cav1.3 CACNA1D; D1 DRD1A;
Transmitter(s): Dopamine;
Simulation Environment: NEURON;
Model Concept(s): Intrinsic plasticity;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; D1; Dopaminergic Receptor; I K,leak; I h; I A, slow; Dopamine;
load_file("nrngui.hoc")
load_file("model_mu_1.ses")	// basic biophysical properties
load_file("fig7syn.hoc")	// use pas to emulate steady state synaptic drive
	// also attach DAsyn point process driven by a NetStim
	// and link the POINTER vars in caL and kir2 to DAsyn[0].msg

/*
  these two lines could be bundled into fig7syn.hoc, 
  but that would make fig7syn.hoc specific to fig. 7a, 
  and I'd have to call it fig7asyn.hoc
*/
syn.tau0 = 1	// rapid rise--not instantaneous, but fast enough for this simulation!
syn.dur = 1e9	// "infinitely" long rise phase

load_file("fig7rig.ses")	// RunControl & Graphs
load_file("fig7acontrol.hoc")	// custom init etc.

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