Spiny neuron model with dopamine-induced bistability (Gruber et al 2003)

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Accession:39949
These files implement a model of dopaminergic modulation of voltage-gated currents (called kir2 and caL in the original paper). See spinycell.html for details of usage and implementation. For questions about this implementation, contact Ted Carnevale (ted.carnevale@yale.edu)
Reference:
1 . Gruber AJ, Solla SA, Surmeier DJ, Houk JC (2003) Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability. J Neurophysiol 90:1095-114 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I K,leak; I h; I A, slow;
Gap Junctions:
Receptor(s): D1; Dopaminergic Receptor;
Gene(s): Cav1.3 CACNA1D; D1 DRD1A;
Transmitter(s): Dopamine;
Simulation Environment: NEURON;
Model Concept(s): Intrinsic plasticity;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; D1; Dopaminergic Receptor; I K,leak; I h; I A, slow; Dopamine;
COMMENT
Described by Gruber et al. 2003.

Gruber, A.J., Solla, S.A., Surmeier, D.J., and Houk, J.C.
Modulation of striatal single units by expected reward: 
a spiny neuron model displaying dopamine-induced bistability.
J. Neurophysiol. 90:1095-1114, 2003.

The paper doesn't state the reversal potential for this current.
However, the figures are reproduced if e_leak equals e_k.
ENDCOMMENT

NEURON {
	SUFFIX leak
	NONSPECIFIC_CURRENT i
	RANGE g, i, iL
	RANGE e
}

UNITS {
	(mA) = (milliamp)
	(uA) = (microamp)
	(mV) = (millivolt)
	(mS) = (millimho)
}

PARAMETER {
	g = 0.008 (mS/cm2)	<0,1e9>
	e = -90	(mV)		: same as e_k in their model
}

ASSIGNED {
	v	(mV)
	iL	(uA/cm2)	: for consistency with their usage of uA/cm2
	i	(mA/cm2)
}

BREAKPOINT {
	iL = g*(v - e)
	i = (0.001)*iL
}

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