Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)

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Accession:50210
The model supports the experimental findings on the effects of postnatal odor deprivation, and shows that a -10mV shift in the Na activation or a reduction in the dendritic length of newborn GC could independently explain the observed increase in excitability.
Reference:
1 . Saghatelyan A, Roux P, Migliore M, Rochefort C, Desmaisons D, Charneau P, Shepherd GM, Lledo PM (2005) Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivation. Neuron 46:103-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Action Potentials; Olfaction;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; AMPA; NMDA; I Na,t; I A; I K; Gaba; Glutamate;
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saghatelyan
readme.txt
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanet.mod
gc-occ.hoc
mitral-occ.hoc
modeldb.zip
mosinit.hoc
occlusion.hoc
                            
begintemplate GC

public somagc, dend, synmt, pridengc, sampa

create somagc, pridengc, dend

objref synmt, sampa

forall Ra=70

proc init() {

topol()
geometry()
segments()
memb()

}


proc topol() {local i
	connect pridengc(0), somagc(1)
	{connect dend(0), pridengc(0.5)}
}

proc segments() {local i
	somagc.nseg= 1
	forsec "den" nseg = 3
}

proc geometry() {local i
	somagc { L = 8  diam = 8}
	forsec "dend" { L=5  diam=0.1}
	pridengc {L=500 nseg=50 diam(0:0.3)=1.5:1.5 diam(0.3:1)=0.8:0.8}
	define_shape()
}
	


proc memb() {
	forall {insert pas }
	forall {insert nax 
		insert kamt 
		insert kdrmt
		gbar_nax = 0.0 
		sh_nax=15
		gbar_kamt = 0.006
	        gbar_kdrmt = 0.0
		}

	forsec "soma" {
		gbar_nax = 0.02
		sh_nax=15
	        gbar_kdrmt = 0.02
	}

	forsec "pridengc" {
	}

	forsec "dend" {
	}

	forall {
		Ra = 70
		cm = 1.5
		g_pas = 1/20000
		e_pas = -65
		ek = -90
		ena = 60
	}

	dend {
	synmt = new nmdanet(1) 
	sampa = new ExpSyn(1)
	sampa.e=0
	sampa.tau=3
	}

}

endtemplate GC

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