Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)

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Accession:50210
The model supports the experimental findings on the effects of postnatal odor deprivation, and shows that a -10mV shift in the Na activation or a reduction in the dendritic length of newborn GC could independently explain the observed increase in excitability.
Reference:
1 . Saghatelyan A, Roux P, Migliore M, Rochefort C, Desmaisons D, Charneau P, Shepherd GM, Lledo PM (2005) Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivation. Neuron 46:103-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Action Potentials; Olfaction;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; AMPA; NMDA; I Na,t; I A; I K; Gaba; Glutamate;
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saghatelyan
readme.txt
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanet.mod
gc-occ.hoc
mitral-occ.hoc
modeldb.zip
mosinit.hoc
occlusion.hoc
                            
begintemplate Mitral

public soma, priden, secden, tuftden, hillock, initialseg, ipgext
public dendritic, somatic, second, somden, synodor, isynpg, igp, igm, igd
public dampa

create soma, priden, secden[2], tuftden, hillock, initialseg

objref dendritic, somatic, second, somden, synodor
objref isynpg, ipgext, igp, igm, igd, dampa

forall Ra=70

proc init() {

dendritic = new SectionList()
forsec "priden" dendritic.append()
forsec "secden" dendritic.append()
forsec "tuftden" dendritic.append()

somatic = new SectionList()
soma somatic.append
hillock somatic.append

somden = new SectionList()
forsec somatic somden.append()
forsec dendritic somden.append()

topol()
segments()
geometry()
memb()

}


proc topol() {local i
	connect secden[0](0), soma(.5)
	connect secden[1](0), soma(.5)
	connect priden(0), soma(1)
	connect tuftden(0), priden(1)

	connect hillock(0), soma(0)
	connect initialseg(0), hillock(1)
}

proc segments() {local i
	soma.nseg= 1
	priden.nseg = 5
	forsec "tuftden" nseg = 10
	forsec "secden" nseg = 10
	initialseg.nseg = 3
	hillock.nseg = 3
}

proc geometry() {local i
	soma { L = 25  diam = 20 }
	priden { L = 300  diam = 3.2 }
	forsec "tuftden" { L=150  diam(0:1)=1.2:0.1 }
	forsec "secden" { L=700  diam=2 }
	initialseg{ L=30  diam=1.5}
	hillock { L=5  diam(0:1) = soma.diam(0) : initialseg.diam(0) }
	define_shape()
}
	


proc memb() {
	forall {insert pas}
	forsec somden {
		insert nax  insert kamt insert kdrmt
		ek = -90
		ena = 50
		gbar_nax = 0.04 sh_nax=10
	 	gbar_kdrmt = 0.0001
		gbar_kamt = 0.004
		}

	forall {Ra = 70}

	totarea=0
	forall {
		for (x) {totarea=totarea+area(x)}
		cm = 1.8
		g_pas = 1/20000
		e_pas = -65
	}
//print "total area ", totarea

	initialseg {
		insert nax  insert kamt insert kdrmt
		ek = -90
		ena = 50
	        g_pas = 1/1000
	        gbar_nax = 0.4
		sh_nax = 0
	        gbar_kamt = 0.04
	        gbar_kdrmt = 0.0001
	}       
  
	tuftden {
	synodor = new Exp2Syn(0.25)
	synodor.e=0
	synodor.tau1 = 0.5
	synodor.tau2 = 500
	isynpg = new Exp2Syn(0.25)
	isynpg.e=-80
	isynpg.tau1 = 1
	isynpg.tau2 = 10
	dampa = new Exp2Syn(0.8)
	dampa.tau1=0.5
	dampa.tau2=100
	dampa.e=0
	}

priden {
	ipgext = new Exp2Syn(0.8)
	ipgext.e=-80
	ipgext.tau1 = 1
	ipgext.tau2 = 100
}

secden {
	igp = new Exp2Syn(0.1)
	igp.e=-80
	igp.tau1 = 1
	igp.tau2 = 10

	igm = new Exp2Syn(0.5)
	igm.e=-80
	igm.tau1 = 1
	igm.tau2 = 10

	igd = new Exp2Syn(0.9)
	igd.e=-80
	igd.tau1 = 1
	igd.tau2 = 10

}
}

endtemplate Mitral

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