Dorsal root ganglion (DRG) neuronal model (Amir, Devor 2003)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:51022
The model shows that an electrically excitable soma is not necessary for spike through-conduction in the t-shaped geometry of a dorsal root ganglion neuron axon. Electrical excitability of the soma is required, however, for soma spike invasion. See papers for details and more.
References:
1 . Amir R, Devor M (2003) Electrical excitability of the soma of sensory neurons is required for spike invasion of the soma, but not for through-conduction. Biophys J 84:2181-91 [PubMed]
2 . Amir R, Devor M (2003) Extra spike formation in sensory neurons and the disruption of afferent spike patterning. Biophys J 84:2700-8 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Myelinated neuron; Dorsal Root Ganglion (DRG) cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials;
Implementer(s): Amir, Ron [ronamir at pob.huji.ac.il];
Search NeuronDB for information about:  I Na,t; I K;
 
/
amirdevor03
                            
File not selected

<- Select file from this column.
Loading data, please wait...