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LTP in cerebellar mossy fiber-granule cell synapses (Saftenku 2002)
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We simulated synaptic transmission and modified a simple model of long-term potentiation (LTP) and long-term depression (LTD) in order to describe long-term plasticity related changes in cerebellar mossy fiber-granule cell synapses. In our model, protein autophosphorylation, leading to the maintenance of long-term plasticity, is controlled by Ca2+ entry through the NMDA receptor channels. The observed nonlinearity in the development of long-term changes of EPSP in granule cells is explained by the difference in the rate constants of two independent autocatalytic processes.
Saftenku EE (2002) A simplified model of long-term plasticity in cerebellar mossy fiber-granule cell synapses.
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Long-term Synaptic Plasticity;
Saftenku, Elena [esaft at biph.kiev.ua];
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