LTP in cerebellar mossy fiber-granule cell synapses (Saftenku 2002)

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Accession:51196
We simulated synaptic transmission and modified a simple model of long-term potentiation (LTP) and long-term depression (LTD) in order to describe long-term plasticity related changes in cerebellar mossy fiber-granule cell synapses. In our model, protein autophosphorylation, leading to the maintenance of long-term plasticity, is controlled by Ca2+ entry through the NMDA receptor channels. The observed nonlinearity in the development of long-term changes of EPSP in granule cells is explained by the difference in the rate constants of two independent autocatalytic processes.
Reference:
1 . Saftenku EE (2002) A simplified model of long-term plasticity in cerebellar mossy fiber-granule cell synapses. Neurophysiology/Neirofiziologiya 34:216-218
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Long-term Synaptic Plasticity; Maintenance;
Implementer(s): Saftenku, Elena [esaft at biph.kiev.ua];
Search NeuronDB for information about:  AMPA; NMDA;
objref Menufig
Menufig=new VBox( ) 
Menufig.intercept(1)    	
xpanel("Fig")
xradiobutton("LTP after 4 bursts at 100 Hz","LTP( )")
xradiobutton("LTD after continuous stimulation at 2 Hz","LTD( )")
xpanel( )
Menufig.intercept(0)
Menufig.map("Granule Cell Plasticity")
proc LTP( ){
for(i=0; i<=NumSyn-1; i=i+1){
Mossy[i].pp.t01=20
Mossy[i].pp.t02=420000
Mossy[i].pp.fast_freq=100
Mossy[i].pp.slow_freq=4
Mossy[i].pp.APinburst=10
Mossy[i].pp.startbursting=2000
Mossy[i].pp.endbursting=3000
t01= Mossy[i].pp.t01
t02= Mossy[i].pp.t02
InSpike= Mossy[i].pp.fast_freq
InBurst= Mossy[i].pp.slow_freq
Spikes= Mossy[i].pp.APinburst
StartIn= Mossy[i].pp.startbursting
EndIn= Mossy[i].pp.endbursting 
UpDateMossy( )

}
}
proc LTD(){
for(i=0;i<=NumSyn-1;i=i+1){
Mossy[i].pp.t01=20
Mossy[i].pp.t02=420000
Mossy[i].pp.fast_freq=2
Mossy[i].pp.slow_freq=0
Mossy[i].pp.APinburst=10
Mossy[i].pp.startbursting=2000
Mossy[i].pp.endbursting= 3500
t01= Mossy[i].pp.t01
t02= Mossy[i].pp.t02
InSpike= Mossy[i].pp.fast_freq
InBurst= Mossy[i].pp.slow_freq
Spikes= Mossy[i].pp.APinburst
StartIn= Mossy[i].pp.startbursting
EndIn= Mossy[i].pp.endbursting 
UpDateMossy( )
}
}

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