LTP in cerebellar mossy fiber-granule cell synapses (Saftenku 2002)

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Accession:51196
We simulated synaptic transmission and modified a simple model of long-term potentiation (LTP) and long-term depression (LTD) in order to describe long-term plasticity related changes in cerebellar mossy fiber-granule cell synapses. In our model, protein autophosphorylation, leading to the maintenance of long-term plasticity, is controlled by Ca2+ entry through the NMDA receptor channels. The observed nonlinearity in the development of long-term changes of EPSP in granule cells is explained by the difference in the rate constants of two independent autocatalytic processes.
Reference:
1 . Saftenku EE (2002) A simplified model of long-term plasticity in cerebellar mossy fiber-granule cell synapses. Neurophysiology/Neirofiziologiya 34:216-218
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Long-term Synaptic Plasticity; Maintenance;
Implementer(s): Saftenku, Elena [esaft at biph.kiev.ua];
Search NeuronDB for information about:  AMPA; NMDA;
objref GRCparams
GRCparams = new VBox()
GRCparams.intercept(1)
   
xpanel("1")   
xlabel("Conductances")
xvalue("gNabar","GrCell[0].soma.gnabar_GrG_Na", 1,"", 0, 0 )
xvalue("gpNabar","GrCell[0].soma.gnabar_GrC_pNa", 1,"", 0, 0 )
xvalue("Aalpha_m","GrCell[0].soma.Aalpha_m_GrC_pNa",1,"",0,0)
xvalue("Abeta_m","GrCell[0].soma.Abeta_m_GrC_pNa",1,"",0,0)
xvalue("gNaresurgent","GrCell[0].soma.gnabar_GrG_Nar", 1,"", 0, 0 )
xvalue("gKVbar","GrCell[0].soma.gkbar_GrG_KV", 1,"", 0, 0 )
xvalue("gKAbar","GrCell[0].soma.gkbar_GrC_KA", 1,"", 0, 0 )
xvalue("Aalpha_a","GrCell[0].soma.Aalpha_a_GrC_KA",1,"",0,0)
xvalue("Abeta_a","GrCell[0].soma.Abeta_a_GrC_KA",1,"",0,0)
xvalue("gKirbar","GrCell[0].soma.gkbar_GrC_Kir", 1,"", 0, 0 )
xvalue("gKCabar","GrCell[0].soma.gkbar_GrC_KCa", 1,"", 0, 0 )
xvalue("gCaHVAbar"," GrCell[0].soma.gcabar_GrC_CaHVA", 1,"", 0, 0 )
xvalue("gKSlowbar"," GrCell[0].soma.gkbar_GrG_KM", 1,"", 0, 0 )
xvalue("gLeakage"," GrCell[0].soma.gl_GrC_Lkg1", 1,"", 0, 0 )
xvalue("gGabaA"," GrCell[0].soma.ggaba_GrC_Lkg2", 1,"", 0, 0 )
xpanel()

xpanel("2")
xlabel("Calcium parameters")
xvalue("Shell thickness"," GrCell[0].soma.d_Calc", 1,"", 0, 0 )
xvalue("Initial concentration"," GrCell[0].soma.cai0_Calc", 1,"", 0, 0 )
xvalue("Removal rate"," GrCell[0].soma.beta_Calc", 1,"", 0, 0 )
xpanel()

GRCparams.intercept(0)
GRCparams.map("Granule Cell Parameters")



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