LTP in cerebellar mossy fiber-granule cell synapses (Saftenku 2002)

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Accession:51196
We simulated synaptic transmission and modified a simple model of long-term potentiation (LTP) and long-term depression (LTD) in order to describe long-term plasticity related changes in cerebellar mossy fiber-granule cell synapses. In our model, protein autophosphorylation, leading to the maintenance of long-term plasticity, is controlled by Ca2+ entry through the NMDA receptor channels. The observed nonlinearity in the development of long-term changes of EPSP in granule cells is explained by the difference in the rate constants of two independent autocatalytic processes.
Reference:
1 . Saftenku EE (2002) A simplified model of long-term plasticity in cerebellar mossy fiber-granule cell synapses. Neurophysiology/Neirofiziologiya 34:216-218
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Long-term Synaptic Plasticity; Maintenance;
Implementer(s): Saftenku, Elena [esaft at biph.kiev.ua];
Search NeuronDB for information about:  AMPA; NMDA;
objref LTPDparams
LTPDparams = new VBox()
LTPDparams.intercept(1)
 
LTP_gamma=GrCell[0].ltp1[0].gamma  
LTP_eta=GrCell[0].ltp1[0].eta  
LTP_nu1=GrCell[0].ltp1[0].nu1  
LTP_nu2=GrCell[0].ltp1[0].nu2  
LTP_pp=GrCell[0].ltp1[0].pp  
LTP_pd=GrCell[0].ltp1[0].pd 
LTP_gdel1=GrCell[0].ltp1[0].gdel1 
LTP_gdel2=GrCell[0].ltp1[0].gdel2 
LTP_Mp=GrCell[0].ltp1[0].Mp 
LTP_Md=GrCell[0].ltp1[0].Md 
LTP_Ap=GrCell[0].ltp1[0].Ap 
LTP_Ad=GrCell[0].ltp1[0].Ad 
ampa_freqdel=GrCell[0].ampa[0].freqdel
nmda_freqdel=GrCell[0].nmda[0].freqdel
Tau_rec= GrCell[0].syn1[0].taurec
Tau_facil= GrCell[0].syn1[0].taufacil
Tau_1= GrCell[0].syn1[0].tauin
U= GrCell[0].syn1[0].usr
u0=GrCell[0].syn1[0].u0

xpanel("1") 
xlabel("Parameters of long-term plasticity")  
xvalue("Gamma (ms-1)","LTP_gamma", 1,"UpDateLTP()", 0, 0 )
xvalue("Eta (ms-1)","LTP_eta", 1,"UpDateLTP()", 0, 0 )
xvalue("Nu1 (ms-1)","LTP_nu1", 1,"UpDateLTP()", 0, 0 )
xvalue("Nu2 (ms-1)","LTP_nu2", 1,"UpDateLTP()", 0, 0 )
xvalue("pp (ms-1)","LTP_pp", 1,"UpDateLTP()", 0, 0 )
xvalue("pd (ms-1)","LTP_pd", 1,"UpDateLTP()", 0, 0 )
xvalue("gdel1(nA-1ms-1)","LTP_gdel1", 1,"UpDateLTP()", 0, 0 )
xvalue("gdel2(nA-1ms-1)","LTP_gdel2", 1,"UpDateLTP()", 0, 0 )
xvalue("Mp (nA/ms)","LTP_Mp", 1,"UpDateLTP()", 0, 0 )
xvalue("Md (nA/ms)","LTP_Md", 1,"UpDateLTP()", 0, 0 )
xvalue("Ap (nA^2)","LTP_Ap", 1,"UpDateLTP()", 0, 0 )
xvalue("Ad (nA^2)","LTP_Ad", 1,"UpDateLTP()", 0, 0 )
xvalue("Freqdel for AMPA (nA-1)","ampa_freqdel", 1,"UpDateLTP()", 0, 0 )
xvalue("Freqdel for NMDA (nA-1)","nmda_freqdel", 1,"UpDateLTP()", 0, 0 )
xpanel()
xpanel("2")
xlabel("Parameters of voltage-dependent and synaptic conductances")
xbutton("Granule cell parameters","param1()")
xbutton("AMPAR parameters","param2()")
xbutton("NMDAR parameters","param3()")
xpanel()
xpanel("3")
xlabel("Parameters of short-term plasticity")
xvalue("Tau decay (ms)","Tau_1", 1,"UpDatePre()", 0, 0 )
xvalue("Tau recovery (ms)","Tau_rec", 1,"UpDatePre()", 0, 0 )
xvalue("Tau facilitation (ms)","Tau_facil", 1,"UpDatePre()", 0, 0 )
xvalue("Use of resources by each AP","U", 1,"UpDatePre()", 0, 0 )
xvalue("Initial facilitated use","u0", 1,"UpDatePre()", 0, 0 )
xpanel()
xpanel("4")
xlabel("Stimulus")
GrCell[0].stim0.del = 1000 
GrCell[0].stim0.dur = 4000
GrCell[0].stim0.amp = 0.00733 
xbutton("IClamp","param5()")
xpanel()

LTPDparams.intercept(0)
LTPDparams.map("Parameters")

proc UpDateLTP(){
	for (i=0;i<=3;i=i+1) {
GrCell[0].ltp1[i].gamma= LTP_gamma 
GrCell[0].ltp1[i].eta= LTP_eta  
GrCell[0].ltp1[i].nu1= LTP_nu1  

GrCell[0].ltp1[i].nu2= LTP_nu2  
GrCell[0].ltp1[i].pp= LTP_pp  
GrCell[0].ltp1[i].pd= LTP_pd 
GrCell[0].ltp1[i].gdel1= LTP_gdel1
GrCell[0].ltp1[i].gdel2= LTP_gdel2
GrCell[0].ltp1[i].Mp= LTP_Mp 
GrCell[0].ltp1[i].Md= LTP_Md 
GrCell[0].ltp1[i].Ap= LTP_Ap
GrCell[0].ltp1[i].Ad = LTP_Ad
GrCell[0].ampa[i].freqdel= ampa_freqdel
GrCell[0].nmda[i].freqdel= nmda_freqdel
}
}
proc UpDatePre(){
	for (i=0;i<=3;i=i+1) {
		GrCell[0].syn1[i].taurec=Tau_rec
		GrCell[0].syn1[i].taufacil=Tau_facil
	      GrCell[0].syn1[i].tauin=Tau_1
		GrCell[0].syn1[i].usr=U
		GrCell[0].syn1[i].u0=u0
}
}
proc param1(){
	xopen("grcparam.hoc")
}
proc param2(){
	xopen("ampa.hoc")
}
proc param3(){
	xopen("nmda.hoc")
}
proc param5(){
	xopen("cclamp.hoc")
}



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