Cortical network model of posttraumatic epileptogenesis (Bush et al 1999)

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Accession:52034
This simulation from Bush, Prince, and Miller 1999 shows the epileptiform response (Fig. 6C) to a brief single stimulation in a 500 cell network of multicompartment models, some of which have active dendrites. The results which I obtained under Redhat Linux is shown in result.gif. Original 1997 code from Paul Bush modified slightly by Bill Lytton to make it work with current version of NEURON (5.7.139). Thanks to Paul Bush and Ken Miller for making the code available.
Reference:
1 . Bush PC, Prince DA, Miller KD (1999) Increased pyramidal excitability and NMDA conductance can explain posttraumatic epileptogenesis without disinhibition: a model. J Neurophysiol 82:1748-58 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex M1 interneuron basket PV GABA cell;
Channel(s): I Na,t; I Sodium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Epilepsy; Synaptic Integration;
Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Bush, Paul;
Search NeuronDB for information about:  Neocortex M1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 interneuron basket PV GABA cell; GabaA; GabaB; AMPA; NMDA; Gaba; I Na,t; I Sodium; I Potassium; Gaba; Glutamate;
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README
AMPA.mod
cadecay.mod
cah.mod
dpresyn.mod
fpoisson_generator.mod
GABAa.mod
GABAb.mod
glu.mod
holt_alphasyn.mod
holt_rnd.mod
kca.mod *
kdr.mod
kdrp.mod
na.mod
nap.mod
NMDA.mod
noise.mod
precall.mod
pregen.mod
seed.mod
Aff
Afi
Aft
Aiaf
Aiat
Aibf
Aibt
Atf
Ati
Att
data.temp
gtstpop.ses
init.hoc
mosinit.hoc *
presyn.inc
result.gif
sns.inc
snsarr.inc
snshead.inc
                            
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295 0 25 0.000722847 1.36611 0
295 0 34 0.0033015 1.83727 0.000489142
295 0 42 0.00168261 2.04044 0.000936681
295 2 77 0.00271418 1.80864 0.00114801
295 0 64 0.00274867 1.47761 0.00098353
295 1 15 0.00306965 1.76234 0.00159258
295 0 1 0.0020542 1.55678 0.00112203
295 0 48 0.000373444 1.4855 0.00223504
295 0 53 0.00155672 2.66914 0.00100753
296 0 5 0.00249114 1.737 0.00177763
296 1 70 0.00171113 0.829266 0.00109409
296 1 38 0.00160613 1.72214 0.00157174
296 2 74 0.00193438 0.5 0.00167232
296 0 51 0.00322612 0.5 0.00139078
296 1 10 0.00294655 1.39432 0.000936652
296 2 24 0.000792832 0.5 0.00172876
296 2 87 0.0013717 0.777828 0.00119254
296 1 12 0.000726954 1.56178 0.00128083
296 1 26 0.0035425 1.38994 0.000859071
297 1 19 0.00170779 0.5 0.00136477
297 0 99 0.00293952 1.83335 0.00102919
297 2 45 0.000821884 1.13848 0.00196857
297 2 65 0.00191396 1.58823 0.000625089
297 0 18 0.00480877 1.03996 0.00138257
297 1 33 0.00408938 2.33493 0.000106496
297 2 38 0.00242721 1.64349 0.000571317
297 0 11 0.00117879 1.39176 0.000874207
297 1 86 0.00242576 1.78582 0.00120872
297 1 21 0.00335778 0.5 0.00103297
298 1 31 0.00260892 1.75669 0.00140882
298 2 54 0.00313992 1.47713 0.00112223
298 0 2 0.00251066 1.46239 0.000860909
298 1 74 0.00406805 0.920126 0.00073575
298 2 37 0.00166619 1.58214 0.00129624
298 1 73 0.00275295 2.04477 0.00136073
298 0 76 0.000772413 0.5 0.000842227
298 1 27 0.00236818 0.772465 0.0012656
298 1 55 0.00226093 2.06833 0.000499781
298 1 48 0.00162446 1.3945 0.0018462
299 1 96 0.00160131 1.21136 0.00147705
299 0 80 0.00106487 2.16559 0.00173647
299 1 57 0.0025908 1.0179 0.00100913
299 0 53 0.000467102 0.5 0.000479046
299 0 85 0.00412998 2.22434 0.000728135
299 2 98 0.00285017 2.26548 0.00201878
299 2 93 0.0018787 1.35465 0.000983908
299 0 54 0.00208062 2.06096 0.000727191
299 0 9 0.00263539 1.21846 0.00141558
299 1 22 0.00132116 3.19909 0.00144659

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