Proximal inhibition of Renshaw cells (Bui et al 2005)

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Accession:58957
Inhibitory synaptic inputs to Renshaw cells are concentrated on the soma and the juxtasomatic dendrites. In the present study, we investigated whether this proximal bias leads to more effective inhibition under different neuronal operating conditions. Using compartmental models based on detailed anatomical measurements of intracellularly stained Renshaw cells, we compared the inhibition produced by GABAA synapses when distributed with a proximal bias to the inhibition produced when the same synapses were distributed uniformly. See paper for more and details.
Reference:
1 . Bui TV, Dewey DE, Fyffe RE, Rose PK (2005) Comparison of the inhibition of Renshaw cells during subthreshold and suprathreshold conditions using anatomically and physiologically realistic models. J Neurophysiol 94:1688-98 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): GabaA; Cholinergic Receptors; Glycine;
Gene(s):
Transmitter(s):
Simulation Environment: SABER;
Model Concept(s): Action Potential Initiation; Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Bui, Tuan V [tuan at biomed.queensu.ca]; Fyffe, Robert EW [robert.fyffe at wright.edu]; Dewey, Dianne E [dianne.dewey at wright.edu]; Rose, P Ken [ken at biomed.queensu.ca];
Search NeuronDB for information about:  GabaA; Cholinergic Receptors; Glycine;
template treed04703	in	out	= Er, Rm, Ri, Cm, mult
electrical	in, out
number	Er = -70m,
	Rm = 5000,
	Ri = 70,
	Cm =1u,
	mult = 1

{
compartment.1_1_0      in         n1_1_0      n1_1_1     =4.6u, 3.6u, Er, Rm, Ri, Cm, mult
synapsetI.113	n1_1_0     	0	=0.65m, -81m, 0m, 0.718n, Rm,Cm
compartment.1_1_2      n1_1_1     n1_1_2      n1_1_3     =2.9u, 2.6u, Er, Rm, Ri, Cm, mult
synapsetI.114	n1_1_2     	0	=0.65m, -81m, 0m, 0.607n, Rm,Cm
compartment.1_1_4      n1_1_3     n1_1_4      n1_1_5     =3.5u, 1.8u, Er, Rm, Ri, Cm, mult
compartment.1_1_6      n1_1_5     n1_1_6      n1_1_7     =4.0u, 1.5u, Er, Rm, Ri, Cm, mult
synapset.201	n1_1_6     	0	=0.20m, 0m, 0m, 0.138n, Rm,Cm
synapsetI.115	n1_1_6     	0	=0.65m, -81m, 0m, 0.603n, Rm,Cm
compartment.1_1_8      n1_1_7     n1_1_8      n1_1_9     =4.6u, 1.4u, Er, Rm, Ri, Cm, mult
compartment.1_1_10     n1_1_9     n1_1_10     n1_1_11    =2.9u, 1.3u, Er, Rm, Ri, Cm, mult
compartment.1_1_12     n1_1_11    n1_1_12     n1_1_13    =3.0u, 1.1u, Er, Rm, Ri, Cm, mult
synapsetI.116	n1_1_12    	0	=0.65m, -81m, 0m, 0.536n, Rm,Cm
compartment.1_1_14     n1_1_13    n1_1_14     n1_1_15    =4.3u, 1.0u, Er, Rm, Ri, Cm, mult
compartment.1_1_16     n1_1_15    n1_1_16     n1_1_17    =7.4u, 0.9u, Er, Rm, Ri, Cm, mult
synapsetI.117	n1_1_16    	0	=0.65m, -81m, 0m, 0.456n, Rm,Cm
compartment.1_1_18     n1_1_17    n1_1_18     n1_1_19    =2.1u, 1.1u, Er, Rm, Ri, Cm, mult
compartment.1_1_20     n1_1_19    n1_1_20     n1_1_21    =3.2u, 1.0u, Er, Rm, Ri, Cm, mult
synapsetI.118	n1_1_20    	0	=0.65m, -81m, 0m, 0.489n, Rm,Cm
compartment.1_1_22     n1_1_21    n1_1_22     n1_1_23    =3.4u, 1.2u, Er, Rm, Ri, Cm, mult
synapset.202	n1_1_22    	0	=0.20m, 0m, 0m, 0.142n, Rm,Cm
compartment.1_1_24     n1_1_23    n1_1_24     n1_1_25    =2.2u, 1.0u, Er, Rm, Ri, Cm, mult
compartment.1_1_26     n1_1_25    n1_1_26     n1_1_27    =18.7u, 1.3u, Er, Rm, Ri, Cm, mult
synapset.203	n1_1_26    	0	=0.20m, 0m, 0m, 0.150n, Rm,Cm
synapsetI.119	n1_1_26    	0	=0.65m, -81m, 0m, 1.632n, Rm,Cm
compartment.2_1_0      n1_1_27    n2_1_0      n2_1_1     =9.8u, 1.0u, Er, Rm, Ri, Cm, mult
synapsetI.120	n2_1_0     	0	=0.65m, -81m, 0m, 0.785n, Rm,Cm
compartment.2_1_2      n2_1_1     n2_1_2      n2_1_3     =2.7u, 1.0u, Er, Rm, Ri, Cm, mult
synapsetI.121	n2_1_2     	0	=0.65m, -81m, 0m, 0.435n, Rm,Cm
compartment.2_1_4      n2_1_3     n2_1_4      n2_1_5     =10.4u, 0.8u, Er, Rm, Ri, Cm, mult
synapsetI.122	n2_1_4     	0	=0.65m, -81m, 0m, 0.409n, Rm,Cm
compartment.2_1_6      n2_1_5     n2_1_6      n2_1_7     =8.5u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.204	n2_1_6     	0	=0.20m, 0m, 0m, 0.139n, Rm,Cm
compartment.2_1_8      n2_1_7     n2_1_8      n2_1_9     =2.9u, 0.9u, Er, Rm, Ri, Cm, mult
synapsetI.123	n2_1_8     	0	=0.65m, -81m, 0m, 0.459n, Rm,Cm
compartment.2_1_10     n2_1_9     n2_1_10     n2_1_11    =4.7u, 0.9u, Er, Rm, Ri, Cm, mult
compartment.2_1_12     n2_1_11    n2_1_12     n2_1_13    =4.1u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.205	n2_1_12    	0	=0.20m, 0m, 0m, 0.161n, Rm,Cm
compartment.2_1_14     n2_1_13    n2_1_14     n2_1_15    =3.5u, 0.8u, Er, Rm, Ri, Cm, mult
compartment.2_1_16     n2_1_15    n2_1_16     n2_1_17    =3.7u, 1.1u, Er, Rm, Ri, Cm, mult
compartment.2_1_18     n2_1_17    n2_1_18     n2_1_19    =3.5u, 1.3u, Er, Rm, Ri, Cm, mult
synapset.206	n2_1_18    	0	=0.20m, 0m, 0m, 0.209n, Rm,Cm
compartment.2_1_20     n2_1_19    n2_1_20     n2_1_21    =7.3u, 1.2u, Er, Rm, Ri, Cm, mult
synapset.207	n2_1_20    	0	=0.20m, 0m, 0m, 0.151n, Rm,Cm
compartment.2_1_22     n2_1_21    n2_1_22     n2_1_23    =10.0u, 1.2u, Er, Rm, Ri, Cm, mult
synapset.208	n2_1_22    	0	=0.20m, 0m, 0m, 0.216n, Rm,Cm
compartment.2_1_24     n2_1_23    n2_1_24     n2_1_25    =7.3u, 1.5u, Er, Rm, Ri, Cm, mult
synapset.209	n2_1_24    	0	=0.20m, 0m, 0m, 0.187n, Rm,Cm
synapsetI.124	n2_1_24    	0	=0.65m, -81m, 0m, 0.435n, Rm,Cm
compartment.2_1_26     n2_1_25    n2_1_26     n2_1_27    =2.4u, 1.5u, Er, Rm, Ri, Cm, mult
compartment.2_1_28     n2_1_27    n2_1_28     n2_1_29    =3.3u, 1.2u, Er, Rm, Ri, Cm, mult
compartment.2_1_30     n2_1_29    n2_1_30     n2_1_31    =2.1u, 1.6u, Er, Rm, Ri, Cm, mult
synapset.210	n2_1_30    	0	=0.20m, 0m, 0m, 0.185n, Rm,Cm
compartment.2_1_32     n2_1_31    n2_1_32     n2_1_33    =4.9u, 1.4u, Er, Rm, Ri, Cm, mult
synapset.211	n2_1_32    	0	=0.20m, 0m, 0m, 0.114n, Rm,Cm
compartment.3_1_0      n2_1_33    n3_1_0      n3_1_1     =4.4u, 1.1u, Er, Rm, Ri, Cm, mult
synapsetI.125	n3_1_0     	0	=0.65m, -81m, 0m, 0.412n, Rm,Cm
compartment.3_1_2      n3_1_1     n3_1_2      n3_1_3     =3.2u, 1.1u, Er, Rm, Ri, Cm, mult
synapset.212	n3_1_2     	0	=0.20m, 0m, 0m, 0.149n, Rm,Cm
compartment.3_1_4      n3_1_3     n3_1_4      n3_1_5     =7.6u, 1.1u, Er, Rm, Ri, Cm, mult
synapset.213	n3_1_4     	0	=0.20m, 0m, 0m, 0.140n, Rm,Cm
compartment.3_1_6      n3_1_5     n3_1_6      n3_1_7     =4.0u, 1.0u, Er, Rm, Ri, Cm, mult
compartment.3_1_8      n3_1_7     n3_1_8      n3_1_9     =7.2u, 0.9u, Er, Rm, Ri, Cm, mult
synapset.214	n3_1_8     	0	=0.20m, 0m, 0m, 0.176n, Rm,Cm
compartment.3_1_10     n3_1_9     n3_1_10     n3_1_11    =5.8u, 0.9u, Er, Rm, Ri, Cm, mult
compartment.3_1_12     n3_1_11    n3_1_12     n3_1_13    =3.0u, 1.1u, Er, Rm, Ri, Cm, mult
synapset.215	n3_1_12    	0	=0.20m, 0m, 0m, 0.155n, Rm,Cm
compartment.3_1_14     n3_1_13    n3_1_14     n3_1_15    =6.9u, 1.1u, Er, Rm, Ri, Cm, mult
compartment.3_1_16     n3_1_15    n3_1_16     n3_1_17    =3.4u, 0.9u, Er, Rm, Ri, Cm, mult
synapset.216	n3_1_16    	0	=0.20m, 0m, 0m, 0.178n, Rm,Cm
compartment.3_1_18     n3_1_17    n3_1_18     n3_1_19    =10.4u, 0.9u, Er, Rm, Ri, Cm, mult
synapset.217	n3_1_18    	0	=0.20m, 0m, 0m, 0.161n, Rm,Cm
synapsetI.126	n3_1_18    	0	=0.65m, -81m, 0m, 0.431n, Rm,Cm
compartment.3_1_20     n3_1_19    n3_1_20     n3_1_21    =3.0u, 0.9u, Er, Rm, Ri, Cm, mult
compartment.3_1_22     n3_1_21    n3_1_22     n3_1_23    =7.6u, 1.1u, Er, Rm, Ri, Cm, mult
synapset.218	n3_1_22    	0	=0.20m, 0m, 0m, 0.194n, Rm,Cm
compartment.3_1_24     n3_1_23    n3_1_24     n3_1_25    =3.2u, 1.1u, Er, Rm, Ri, Cm, mult
synapsetI.127	n3_1_24    	0	=0.65m, -81m, 0m, 0.451n, Rm,Cm
compartment.3_1_26     n3_1_25    n3_1_26     n3_1_27    =8.2u, 0.9u, Er, Rm, Ri, Cm, mult
synapset.219	n3_1_26    	0	=0.20m, 0m, 0m, 0.180n, Rm,Cm
compartment.3_1_28     n3_1_27    n3_1_28     n3_1_29    =7.6u, 0.9u, Er, Rm, Ri, Cm, mult
compartment.3_1_30     n3_1_29    n3_1_30     n3_1_31    =3.8u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.220	n3_1_30    	0	=0.20m, 0m, 0m, 0.150n, Rm,Cm
compartment.3_1_32     n3_1_31    n3_1_32     n3_1_33    =17.3u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.221	n3_1_32    	0	=0.20m, 0m, 0m, 0.213n, Rm,Cm
compartment.3_1_34     n3_1_33    n3_1_34     n3_1_35    =9.0u, 0.8u, Er, Rm, Ri, Cm, mult
compartment.3_1_36     n3_1_35    n3_1_36     n3_1_37    =3.7u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.222	n3_1_36    	0	=0.20m, 0m, 0m, 0.164n, Rm,Cm
compartment.3_1_38     n3_1_37    n3_1_38     n3_1_39    =3.7u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.3_1_40     n3_1_39    n3_1_40     n3_1_41    =3.5u, 0.6u, Er, Rm, Ri, Cm, mult
compartment.3_1_42     n3_1_41    n3_1_42     n3_1_43    =3.2u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.3_1_44     n3_1_43    n3_1_44     n3_1_45    =3.5u, 0.8u, Er, Rm, Ri, Cm, mult
synapset.223	n3_1_44    	0	=0.20m, 0m, 0m, 0.169n, Rm,Cm
compartment.3_1_46     n3_1_45    n3_1_46     n3_1_47    =3.8u, 0.8u, Er, Rm, Ri, Cm, mult
compartment.3_1_48     n3_1_47    n3_1_48     n3_1_49    =3.2u, 0.6u, Er, Rm, Ri, Cm, mult
synapsetI.128	n3_1_48    	0	=0.65m, -81m, 0m, 0.418n, Rm,Cm
compartment.3_1_50     n3_1_49    n3_1_50     n3_1_51    =3.8u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.3_1_52     n3_1_51    n3_1_52     n3_1_53    =5.5u, 0.8u, Er, Rm, Ri, Cm, mult
synapset.224	n3_1_52    	0	=0.20m, 0m, 0m, 0.205n, Rm,Cm
compartment.3_1_54     n3_1_53    n3_1_54     n3_1_55    =8.1u, 0.8u, Er, Rm, Ri, Cm, mult
compartment.3_1_56     n3_1_55    n3_1_56     n3_1_57    =2.5u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.225	n3_1_56    	0	=0.20m, 0m, 0m, 0.138n, Rm,Cm
compartment.3_1_58     n3_1_57    n3_1_58     n3_1_59    =9.1u, 0.7u, Er, Rm, Ri, Cm, mult
synapsetI.129	n3_1_58    	0	=0.65m, -81m, 0m, 0.198n, Rm,Cm
compartment.3_1_60     n3_1_59    n3_1_60     n3_1_61    =3.3u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.226	n3_1_60    	0	=0.20m, 0m, 0m, 0.148n, Rm,Cm
compartment.3_1_62     n3_1_61    n3_1_62     n3_1_63    =5.4u, 0.7u, Er, Rm, Ri, Cm, mult
ecompartment.3_1_64    n3_1_63    n3_1_64     =4.3u, 0.5u, Er, Rm, Ri, Cm, mult
synapset.227	n3_1_64    	0	=0.20m, 0m, 0m, 0.092n, Rm,Cm
compartment.3_2_0      n2_1_33    n3_2_0      n3_2_1     =3.9u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.3_2_2      n3_2_1     n3_2_2      n3_2_3     =6.4u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.228	n3_2_2     	0	=0.20m, 0m, 0m, 0.143n, Rm,Cm
compartment.3_2_4      n3_2_3     n3_2_4      n3_2_5     =3.1u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.3_2_6      n3_2_5     n3_2_6      n3_2_7     =1.4u, 0.9u, Er, Rm, Ri, Cm, mult
synapsetI.130	n3_2_6     	0	=0.65m, -81m, 0m, 0.416n, Rm,Cm
compartment.3_2_8      n3_2_7     n3_2_8      n3_2_9     =4.3u, 0.8u, Er, Rm, Ri, Cm, mult
compartment.3_2_10     n3_2_9     n3_2_10     n3_2_11    =2.1u, 0.9u, Er, Rm, Ri, Cm, mult
synapset.229	n3_2_10    	0	=0.20m, 0m, 0m, 0.155n, Rm,Cm
compartment.3_2_12     n3_2_11    n3_2_12     n3_2_13    =6.3u, 1.1u, Er, Rm, Ri, Cm, mult
compartment.3_2_14     n3_2_13    n3_2_14     n3_2_15    =3.4u, 0.8u, Er, Rm, Ri, Cm, mult
synapset.230	n3_2_14    	0	=0.20m, 0m, 0m, 0.158n, Rm,Cm
compartment.3_2_16     n3_2_15    n3_2_16     n3_2_17    =8.4u, 0.8u, Er, Rm, Ri, Cm, mult
compartment.3_2_18     n3_2_17    n3_2_18     n3_2_19    =4.0u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.231	n3_2_18    	0	=0.20m, 0m, 0m, 0.154n, Rm,Cm
compartment.3_2_20     n3_2_19    n3_2_20     n3_2_21    =10.7u, 0.5u, Er, Rm, Ri, Cm, mult
synapsetI.131	n3_2_20    	0	=0.65m, -81m, 0m, 0.411n, Rm,Cm
compartment.3_2_22     n3_2_21    n3_2_22     n3_2_23    =6.7u, 0.5u, Er, Rm, Ri, Cm, mult
synapset.232	n3_2_22    	0	=0.20m, 0m, 0m, 0.151n, Rm,Cm
compartment.3_2_24     n3_2_23    n3_2_24     n3_2_25    =16.5u, 0.6u, Er, Rm, Ri, Cm, mult
synapset.233	n3_2_24    	0	=0.20m, 0m, 0m, 0.169n, Rm,Cm
compartment.3_2_26     n3_2_25    n3_2_26     n3_2_27    =15.1u, 0.6u, Er, Rm, Ri, Cm, mult
synapset.234	n3_2_26    	0	=0.20m, 0m, 0m, 0.155n, Rm,Cm
compartment.3_2_28     n3_2_27    n3_2_28     n3_2_29    =16.9u, 0.6u, Er, Rm, Ri, Cm, mult
synapset.235	n3_2_28    	0	=0.20m, 0m, 0m, 0.173n, Rm,Cm
compartment.3_2_30     n3_2_29    n3_2_30     n3_2_31    =13.7u, 0.6u, Er, Rm, Ri, Cm, mult
synapsetI.132	n3_2_30    	0	=0.65m, -81m, 0m, 0.361n, Rm,Cm
ecompartment.3_2_32    n3_2_31    n3_2_32     =45.9u, 0.3u, Er, Rm, Ri, Cm, mult
synapset.236	n3_2_32    	0	=0.20m, 0m, 0m, 0.366n, Rm,Cm
compartment.2_2_0      n1_1_27    n2_2_0      n2_2_1     =12.2u, 0.5u, Er, Rm, Ri, Cm, mult
synapsetI.133	n2_2_0     	0	=0.65m, -81m, 0m, 0.823n, Rm,Cm
compartment.2_2_2      n2_2_1     n2_2_2      n2_2_3     =1.5u, 0.5u, Er, Rm, Ri, Cm, mult
synapsetI.134	n2_2_2     	0	=0.65m, -81m, 0m, 0.404n, Rm,Cm
compartment.2_2_4      n2_2_3     n2_2_4      n2_2_5     =11.4u, 0.5u, Er, Rm, Ri, Cm, mult
compartment.2_2_6      n2_2_5     n2_2_6      n2_2_7     =2.2u, 0.6u, Er, Rm, Ri, Cm, mult
compartment.2_2_8      n2_2_7     n2_2_8      n2_2_9     =2.9u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.237	n2_2_8     	0	=0.20m, 0m, 0m, 0.113n, Rm,Cm
synapsetI.135	n2_2_8     	0	=0.65m, -81m, 0m, 0.095n, Rm,Cm
compartment.2_2_10     n2_2_9     n2_2_10     n2_2_11    =15.2u, 0.6u, Er, Rm, Ri, Cm, mult
synapset.238	n2_2_10    	0	=0.20m, 0m, 0m, 0.160n, Rm,Cm
compartment.2_2_12     n2_2_11    n2_2_12     n2_2_13    =5.7u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.2_2_14     n2_2_13    n2_2_14     n2_2_15    =5.5u, 1.0u, Er, Rm, Ri, Cm, mult
synapset.239	n2_2_14    	0	=0.20m, 0m, 0m, 0.172n, Rm,Cm
synapsetI.136	n2_2_14    	0	=0.65m, -81m, 0m, 0.419n, Rm,Cm
compartment.2_2_16     n2_2_15    n2_2_16     n2_2_17    =6.4u, 0.9u, Er, Rm, Ri, Cm, mult
compartment.2_2_18     n2_2_17    n2_2_18     n2_2_19    =3.7u, 0.8u, Er, Rm, Ri, Cm, mult
synapset.240	n2_2_18    	0	=0.20m, 0m, 0m, 0.144n, Rm,Cm
compartment.2_2_20     n2_2_19    n2_2_20     n2_2_21    =7.8u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.241	n2_2_20    	0	=0.20m, 0m, 0m, 0.097n, Rm,Cm
compartment.3_3_0      n2_2_21    n3_3_0      n3_3_1     =5.8u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.3_3_2      n3_3_1     n3_3_2      n3_3_3     =2.9u, 0.7u, Er, Rm, Ri, Cm, mult
compartment.3_3_4      n3_3_3     n3_3_4      n3_3_5     =3.2u, 0.8u, Er, Rm, Ri, Cm, mult
synapset.242	n3_3_4     	0	=0.20m, 0m, 0m, 0.160n, Rm,Cm
compartment.3_3_6      n3_3_5     n3_3_6      n3_3_7     =2.2u, 0.8u, Er, Rm, Ri, Cm, mult
compartment.3_3_8      n3_3_7     n3_3_8      n3_3_9     =4.4u, 1.1u, Er, Rm, Ri, Cm, mult
compartment.3_3_10     n3_3_9     n3_3_10     n3_3_11    =1.8u, 0.8u, Er, Rm, Ri, Cm, mult
synapset.243	n3_3_10    	0	=0.20m, 0m, 0m, 0.139n, Rm,Cm
ecompartment.3_3_12    n3_3_11    n3_3_12     =13.5u, 0.7u, Er, Rm, Ri, Cm, mult
synapset.244	n3_3_12    	0	=0.20m, 0m, 0m, 0.161n, Rm,Cm
synapsetI.137	n3_3_12    	0	=0.65m, -81m, 0m, 0.337n, Rm,Cm
compartment.3_4_0      n2_2_21    n3_4_0      n3_4_1     =3.4u, 0.6u, Er, Rm, Ri, Cm, mult
compartment.3_4_2      n3_4_1     n3_4_2      n3_4_3     =5.7u, 0.6u, Er, Rm, Ri, Cm, mult
synapsetI.138	n3_4_2     	0	=0.65m, -81m, 0m, 0.132n, Rm,Cm
ecompartment.3_4_4     n3_4_3     n3_4_4      =7.7u, 0.6u, Er, Rm, Ri, Cm, mult
synapset.245	n3_4_4     	0	=0.20m, 0m, 0m, 0.180n, Rm,Cm
}

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