Proximal inhibition of Renshaw cells (Bui et al 2005)

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Inhibitory synaptic inputs to Renshaw cells are concentrated on the soma and the juxtasomatic dendrites. In the present study, we investigated whether this proximal bias leads to more effective inhibition under different neuronal operating conditions. Using compartmental models based on detailed anatomical measurements of intracellularly stained Renshaw cells, we compared the inhibition produced by GABAA synapses when distributed with a proximal bias to the inhibition produced when the same synapses were distributed uniformly. See paper for more and details.
1 . Bui TV, Dewey DE, Fyffe RE, Rose PK (2005) Comparison of the inhibition of Renshaw cells during subthreshold and suprathreshold conditions using anatomically and physiologically realistic models. J Neurophysiol 94:1688-98 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions:
Receptor(s): GabaA; Cholinergic Receptors; Glycine;
Simulation Environment: SABER;
Model Concept(s): Action Potential Initiation; Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Bui, Tuan V [tuan at]; Fyffe, Robert EW [robert.fyffe at]; Dewey, Dianne E [dianne.dewey at]; Rose, P Ken [ken at];
Search NeuronDB for information about:  GabaA; Cholinergic Receptors; Glycine;
element template synapse_glycine_GABA		in  out	= esyn, td, gpeak, Rm, Cm

electrical	in, out

number	esyn = -64m,
		td = 0,
		gpeak = 12.2n,
		Rm = 15000,
		Cm = 1u


number	tp = 0.37m,
		tdecay1 = 3.1m,
		tdecay2 = 14.1m,
		A = 0.74, 
		B = 0.26
val g	gsyn
val v	vm
val i	i
val nu T

values	{
	T = (time - td)

	vm = v(in) - v(out)

	if (time < td){
		i = 0

	else	{
	      #if (T < tp){
		#	i = -(vm - esyn) * gpeak*(T)*(exp(1-T/tp))/tp
		#else {
		#	i = -(vm - esyn) * gpeak*(A*exp(-(T - tp)/tdecay1) + B*exp(-(T - tp)/tdecay2))
		if (time < tp){
			gsyn = gpeak * (T)*(exp(1-T/tp))/tp
			i = -(vm - esyn) * gsyn 
		else {
			gsyn = gpeak*(A*exp(-(T - tp)/tdecay1) + B*exp(-(T - tp)/tdecay2))
			i = -(vm - esyn) * gsyn 

equations 	{
	i(in->out) += i


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