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IA and IT interact to set first spike latency (Molineux et al 2005)
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Using patch clamp and modeling, we illustrate that spike latency characteristics are the product of an interplay between I(A) and low-threshold calcium current (I(T)) that requires a steady-state difference in the inactivation parameters of the currents. Furthermore, we show that the unique first-spike latency characteristics of stellate cells have important implications for the integration of coincident IPSPs and EPSPs, such that inhibition can shift first-spike latency to differentially modulate the probability of firing.
Molineux ML, Fernandez FR, Mehaffey WH, Turner RW (2005) A-type and T-type currents interact to produce a novel spike latency-voltage relationship in cerebellar stellate cells.
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Neuron or other electrically excitable cell;
I T low threshold;
Action Potential Initiation;
Fernandez FR [ffernand at ucalgary.ca];
Mehaffey WH ;
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I T low threshold
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