Voltage attenuation in CA1 pyramidal neuron dendrites (Golding et al 2005)


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Accession:64170
Voltage attenuation in the apical dendritic field of CA1 pyramidal neurons is particularly strong for epsps spreading toward the soma. High cytoplasmic resistivity and high membrane (leak) conductance appear to be the major determinants of voltage attenuation over most of the apical field, but H current may be responsible for as much as half of the attenuation of distal apical epsps.
Reference:
1 . Golding NL, Mickus TJ, Katz Y, Kath WL, Spruston N (2005) Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. J Physiol 568:69-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model);
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Integration; Electrotonus;
Implementer(s): Spruston, Nelson [Spruston at Northwestern.edu]; Golding, Nace L [golding at mail.utexas.edu]; Kath, William L [kath at northwestern.edu]; Mickus, Timothy ; Katz, Yael [y-katz at northwestern.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; I h;
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