Rat subthalamic projection neuron (Gillies and Willshaw 2006)

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Accession:74298
A computational model of the rat subthalamic nucleus projection neuron is constructed using electrophysiological and morphological data and a restricted set of channel specifications. The model cell exhibits a wide range of electrophysiological behaviors characteristic of rat subthalamic neurons. It reveals that a key set of three channels play a primary role in distinguishing behaviors: a high-voltage-activated calcium channel (Cav 1.2.-1.3), a low-voltage-activated calcium channel (Cav 3.-), and a small current calcium-activated potassium channel (KCa 2.1-2.3). See paper for more and details.
Reference:
1 . Gillies A, Willshaw D (2006) Membrane channel interactions underlying rat subthalamic projection neuron rhythmic and bursting activity. J Neurophysiol 95:2352-65 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Subthalamus nucleus projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I K; I h; I K,Ca; I Calcium; I Mixed;
Gap Junctions:
Receptor(s):
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; KCa2.1 KCNN1; Kv2.1 KCNB1; Kv3.1 KCNC1; HCN Cnga1; Cav2.2 CACNA1B; KCa2.2 KCNN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting;
Implementer(s): Gillies, Andrew [andrew at anc.ed.ac.uk];
Search NeuronDB for information about:  I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I K; I h; I K,Ca; I Calcium; I Mixed;
load_file("nrngui.hoc")

xpanel("Examples from Gillies & Willshaw 2006")
xlabel("This set of simulations will produce seven graphs")
xlabel("showing the following model subthalamic physiology")
xlabel("   1. the shape of the action potential.")
xlabel("   2. spontaneous rest firing at 25 degC.")
xlabel("   3. spontaneous rest firing at 37 degC.")
xlabel("   4. post hyperpolarising rebound burst.")
xlabel("   5. low frequency (<1Hz) rhythmic bursting.")
xlabel("   6. high frequency (>1Hz) rhythmic bursting.")
xlabel("   7. mixed mode rhythmic bursting.")
xlabel("Each graph takes 1-2 minutes (on a 2GHz PC).")

xbutton("Begin", "load_file(1,\"sample.hoc\")")
xlabel("Click the above button to begin the simulations.")

xpanel(10,110)


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