Rat subthalamic projection neuron (Gillies and Willshaw 2006)

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Accession:74298
A computational model of the rat subthalamic nucleus projection neuron is constructed using electrophysiological and morphological data and a restricted set of channel specifications. The model cell exhibits a wide range of electrophysiological behaviors characteristic of rat subthalamic neurons. It reveals that a key set of three channels play a primary role in distinguishing behaviors: a high-voltage-activated calcium channel (Cav 1.2.-1.3), a low-voltage-activated calcium channel (Cav 3.-), and a small current calcium-activated potassium channel (KCa 2.1-2.3). See paper for more and details.
Reference:
1 . Gillies A, Willshaw D (2006) Membrane channel interactions underlying rat subthalamic projection neuron rhythmic and bursting activity. J Neurophysiol 95:2352-65 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Subthalamus nucleus projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I K; I h; I K,Ca; I Calcium; I Mixed;
Gap Junctions:
Receptor(s):
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; KCa2.1 KCNN1; Kv2.1 KCNB1; Kv3.1 KCNC1; HCN Cnga1; Cav2.2 CACNA1B; KCa2.2 KCNN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting;
Implementer(s): Gillies, Andrew [andrew at anc.ed.ac.uk];
Search NeuronDB for information about:  I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I K; I h; I K,Ca; I Calcium; I Mixed;
1 2 3 3.0973 10.0000 2
2 4 5 1.9480 40.0000 2
3 14 15 1.9480 40.0000 2
4 6 7 1.2272 40.0000 2
5 10 11 1.2272 40.0000 2
14 16 17 1.2272 40.0000 2
15 20 21 1.2272 40.0000 2
6 8 9 0.7695 100.0000 4
8 0 0 0.4870 150.0000 6
9 0 0 0.4870 150.0000 6
7 0 0 0.7695 289.0000 12
10 0 0 0.7695 289.0000 12
11 12 13 0.7695 100.0000 4
12 0 0 0.4870 150.0000 6
13 0 0 0.4870 150.0000 6
16 18 19 0.7695 100.0000 4
18 0 0 0.4870 150.0000 6
19 0 0 0.4870 150.0000 6
17 0 0 0.7695 289.0000 12
20 0 0 0.7695 289.0000 12
21 22 23 0.7695 100.0000 4
22 0 0 0.4870 150.0000 6
23 0 0 0.4870 150.0000 6

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