ModelDB: CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)

CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)

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Accession:87535

NEURON files from the paper: Single neuron binding properties and the magical number 7, by M. Migliore, G. Novara, D. Tegolo, Hippocampus, in press (2008). In an extensive series of simulations with realistic morphologies and active properties, we demonstrate how n radial (oblique) dendrites of these neurons may be used to bind n inputs to generate an output signal. The results suggest a possible neural code as the most effective n-ple of dendrites that can be used for short-term memory recollection of persons, objects, or places. Our analysis predicts a straightforward physiological explanation for the observed puzzling limit of about 7 short-term memory items that can be stored by humans.
Reference:
1 . Migliore M, Novara G, Tegolo D (2008) Single neuron binding properties and the magical number 7. Hippocampus 18:1122-30 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I A; I K; I h; I Sodium;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Pattern Recognition; Activity Patterns; Dendritic Action Potentials; Coincidence Detection; Spatio-temporal Activity Patterns; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Working memory; Learning; Action Selection/Decision Making;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];