Lamprey spinal CPG neuron (Huss et al. 2007)

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Accession:93319
This is a model of a generic locomotor network neuron in the lamprey spinal cord. The given version is assumed to correspond to an interneuron; motoneurons can also be modelled by changing the dendritic tree morphology.
Reference:
1 . Huss M, Lansner A, Wallén P, El Manira A, Grillner S, Kotaleski JH (2007) Roles of ionic currents in lamprey CpG neurons: a modeling study. J Neurophysiol 97:2696-711 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I A; I K; I K,Ca; I_Ks;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Rebound firing;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,Ca; I_Ks;
float PI = 3.141592654

int	i
float dt = 1e-5
float sim_time = 0.1
setclock 0 {dt}
setclock 1 0.0001
setmethod 11
//setmethod 0

float NMDA=0.0
float AMPA=0.0

float Vrest	= -0.07

include library_ein
include finish
include output

make_cell dissociated_cell.p neuron

setfield /neuron/soma/KCa_NMDA	Z	0.0
setfield /neuron/soma/KCa_HVA	Z	0.0

// Apply 'cadmium', blocking Ca currents

setfield /neuron/soma/Ca_HVA Gbar {0.0*{getfield /neuron/soma/Ca_HVA Gbar}}
// setfield /neuron/primdend1/Ca_HVA Gbar 0
// setfield /neuron/primdend2/Ca_HVA Gbar 0
setfield /neuron/soma/Ca_L Gbar {0.0*{getfield /neuron/soma/Ca_L Gbar}}
setfield /neuron/soma/Ca_LVA Gbar {0.0*{getfield /neuron/soma/Ca_LVA Gbar}}
// setfield /neuron/primdend1/Ca_L Gbar 0
// setfield /neuron/primdend2/Ca_L Gbar 0


include xout_diss

// if hsolve is used
call /neuron SETUP

reset

float	I
float Imax = {3.14159};
 
 step 0.020 -t

 float inj = 0.9e-9;

 setfield /neuron/soma inject {inj}
 step 20e-3 -t
 setfield /neuron/soma inject 0.0
 step 2e-3 -t   
 setfield /neuron/soma inject {inj}
 step 20e-3 -t
 setfield /neuron/soma inject 0
 step 50e-3 -t















































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