Cortical fast-spiking (FS) interneurons display highly variable electrophysiological properties. We hypothesize that this variability emerges naturally if one assumes a continuous distribution of properties in a small set of active channels. We construct a minimal, single-compartment conductance-based model of FS cells that includes transient Na+, delayed-rectifier K+, and slowly inactivating d-type K+ conductances. The model may display delay to firing. Stuttering (elliptic bursting) and subthreshold oscillations may be observed for small Na+ window current.
Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007) Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons. PLoS Comput Biol 3:e156 [PubMed]