Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)

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Accession:97874
NQS is a databasing program with a query command modeled loosely on the SQL select command. Please see the manual NQS.pdf for details of use. An NQS database must be populated with data to be used. This package includes MFP (model fingerprint) which provides an example of NQS use with the model provided in the modeldb folder (see readme for usage).
Reference:
1 . Lytton WW (2006) Neural Query System: Data-mining from within the NEURON simulator. Neuroinformatics 4:163-76 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Methods;
Implementer(s): Lytton, William [bill.lytton at downstate.edu];
/
NQS_with_example
modeldb
readme.txt *
exp2i.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3s.mod *
naxn.mod *
netstims.mod *
nmdanet.mod *
vecst.mod *
forfig5A.hoc *
n160.nrn *
orig_mosinit.hoc *
                            
NEURON mod files from the paper:
Sonia Gasparini, Michele Migliore, and Jeffrey C. Magee
On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons,
J.Neurosci. 24:11046-11056 (2004).

The paper investigates the dendritic spike probability as a function 
of the number of activated synaptic input and their spatial and temporal distribution.
The results suggest that highly synchronized and moderately clustered inputs 
have the highest probability to generate a dendritic spike.

The main effect is demonstrated here by reproducing the simulations
in Fig.5A of the paper, in which 5 synapses were activated 
in the same compartment with different time delays.
Simulations can be run for different kind of synaptic input:
- current pulses 
- AMPA 
- AMPA+NMDA

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui forfig5A.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
forfig5A.hoc 
will open the simulation window.

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it



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