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Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
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Model Information
Model File
Citations
Accession:
102279
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 .
Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech.
J Neurophysiol
99
:605-16
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Axon;
Brain Region(s)/Organism:
Cell Type(s):
Leech S cell;
Channel(s):
I Na,t;
I L high threshold;
I K;
I K,leak;
I K,Ca;
I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
SNNAP;
Model Concept(s):
Implementer(s):
Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB
for information about:
I Na,t
;
I L high threshold
;
I K
;
I K,leak
;
I K,Ca
;
I Sodium
;
Download the displayed file
/
leechSCell
readme.txt
ADP.m
*
Other models using ADP.m:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
ADP.vdg
*
Other models using ADP.vdg:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Ca.fBR
*
Other models using Ca.fBR:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Ca.ion
*
Other models using Ca.ion:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Ca.ion.tmp
*
Other models using Ca.ion.tmp:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Ca.m
*
Other models using Ca.m:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Ca.vdg
*
Other models using Ca.vdg:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
fAHP.m
*
Other models using fAHP.m:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
fAHP.vdg
*
Other models using fAHP.vdg:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Kdr.m
*
Other models using Kdr.m:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Kdr.vdg
*
Other models using Kdr.vdg:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
leak.vdg
mAHP.A
*
Other models using mAHP.A:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
mAHP.vdg
*
Other models using mAHP.vdg:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Na.h
*
Other models using Na.h:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Na.m
*
Other models using Na.m:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Na.vdg
*
Other models using Na.vdg:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
netwf
*
Other models using netwf:
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
netwfile
*
Other models using netwfile:
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
ousgrf.def
*
Other models using ousgrf.def:
A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Serotonergic modulation of Aplysia sensory neurons (Baxter et al 1999)
SCell.neu
SCell.ntw
simufiles.usd
single.ous
single.ous.mnu
single.smu
single.smu.exec
single.smu.hmn
*
Other models using single.smu.hmn:
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
single.smu.ing
single.smu.out
single.smu.out.head
single.trt
singlezoom.ous
singlezoom.ous.mnu
singlezoom.smu
singlezoom.smu.exec
singlezoom.smu.hmn
*
Other models using singlezoom.smu.hmn:
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
singlezoom.smu.ing
singlezoom.smu.out
singlezoom.smu.out.head
train.ous
train.ous.mnu
train.smu
train.smu.exec
train.smu.hmn
*
Other models using train.smu.hmn:
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
train.smu.ing
train.smu.out
train.smu.out.head
train.trt
NEURONS SCell SCell.neu green CONNECTIONS
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