Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

 Download zip file 
Help downloading and running models
Accession:102279
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 . Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech. J Neurophysiol 99:605-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Leech S cell;
Channel(s): I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s):
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
/
leechSCell
readme.txt
ADP.m *
ADP.vdg *
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
fAHP.m *
fAHP.vdg *
Kdr.m *
Kdr.vdg *
leak.vdg
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf *
netwfile *
ousgrf.def *
SCell.neu
SCell.ntw
simufiles.usd
single.ous
single.ous.mnu
single.smu
single.smu.exec
single.smu.hmn *
single.smu.ing
single.smu.out
single.smu.out.head
single.trt
singlezoom.ous
singlezoom.ous.mnu
singlezoom.smu
singlezoom.smu.exec
singlezoom.smu.hmn *
singlezoom.smu.ing
singlezoom.smu.out
singlezoom.smu.out.head
train.ous
train.ous.mnu
train.smu
train.smu.exec
train.smu.hmn *
train.smu.ing
train.smu.out
train.smu.out.head
train.trt
                            
>------------------------------->--------------------------------------->
  VAR_TO_GRAPH: 		>	List of current contributing	>
				>		to ion pools		>
>------------------------------->--------------------------------------->
	GRPH_CHNL:		>	Graph channel			>
>------------------------------->--------------------------------------->
	1			>	GAIN of Channel			>
	time<{ivr}            	>	Var Name for X-axis		>
		10          	>	Number of Tic Marks		>
		0.10        	>	Min Value of X			>
		0.50        	>	Max Value of X			>
		red          	>	Color of Range			>
	V[SCell....]<{svr}    	>	Var Name for Y-axis		>
		10          	>	Number of Tic Marks		>
		-70.00      	>	Min Value of Y			>
		50.00       	>	Max Value of Y			>
		red           	>	Color of RAnge			>
>------------------------------->--------------------------------------->
	END:			>					>
>------------------------------->--------------------------------------->

>------------------------------->--------------------------------------->
   VAR_TO_FILE: 		>	List of current contributing	>
>				>		to ion pools		>
>------------------------------->--------------------------------------->
	time<{ivr}             	>	VAR name			>
	V[SCell....]<{svr}     	>	VAR name			>
>------------------------------->--------------------------------------->
	END:			>					>
>------------------------------->--------------------------------------->

END:

Loading data, please wait...