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Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

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Accession:102279
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 . Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech. J Neurophysiol 99:605-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Leech S cell;
Channel(s): I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s):
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
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leechSCell
readme.txt
ADP.m *
ADP.vdg *
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
fAHP.m *
fAHP.vdg *
Kdr.m *
Kdr.vdg *
leak.vdg
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf *
netwfile *
ousgrf.def *
SCell.neu
SCell.ntw
simufiles.usd
single.ous
single.ous.mnu
single.smu
single.smu.exec
single.smu.hmn *
single.smu.ing
single.smu.out
single.smu.out.head
single.trt
singlezoom.ous
singlezoom.ous.mnu
singlezoom.smu
singlezoom.smu.exec
singlezoom.smu.hmn *
singlezoom.smu.ing
singlezoom.smu.out
singlezoom.smu.out.head
train.ous
train.ous.mnu
train.smu
train.smu.exec
train.smu.hmn *
train.smu.ing
train.smu.out
train.smu.out.head
train.trt
                            
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		>>    modules name< ION		>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Cion:		> 	Concentration of an ion				>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

>----------------------->------------------------------------------------------>
>	1		>						       >
>	0.	>Vc< 	>				-------		       >
>	0.	>K1<	>				       \	       >
>	0.	>K2<	>				        \	       >
>	0.	>K3<	>	dCion     CIion - Iu - Id	|	       >
>	0.	>Dgain<	>	----- = -----------------	|	       >
>	0.	>Dmid<	>	 dt             Vc		|	       >
>	0.	>p<	>					|	       >
>			>		     +--       -+	|	       >
>			>		     | -------  |	|	       >
>			>		     | \        |	|	       >
>			>	CIion = K1 x |- > Iion  | - K2	|	       >
>			>		     | /        |	 >	(1)    >
>			>		     | -------  |	|	       >
>			>		     +--       -+	|	       >
>			>					|	       >
>			>		Dgain			|	       >
>			>	Iu = ---------------		|	       >
>			>			    p		|	       >
>			>		1+ dmid/Cion		|	       >
>			>					|	       >
>			>	Id = K3 x Cion			|	       >
>			>					/	       >
>			>				       /	       >
>			>				-------		       >
>			>						       >
>----------------------->------------------------------------------------------>
	2		>		    |     +-	    -+       |	       >
	5.0		>K1<	>		    |     | -------  |	     |	       >
	1.0		>K2<	>	dCion	    |     | \        |	     |	       >
			>	-----= K1 x |K2 x |- > Iion  | -Cion |	(2)    >
			>		    |     | -------  |	     |	       >
			>		    |     +-	    -+       |	       >

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