Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)

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Accession:112685
"... Our results suggest that a complex complement of ionic mechanisms is needed to fine-tune separate aspects of the neuronal response dynamics. Simulations also suggest that the Golgi cell may exploit these mechanisms to obtain a fine regulation of timing of incoming mossy fiber responses and granular layer circuit oscillation and bursting."
References:
1 . Solinas S, Forti L, Cesana E, Mapelli J, De Schutter E, D'Angelo E (2007) Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. Front Cell Neurosci 1:2 [PubMed]
2 . Solinas S, Forti L, Cesana E, Mapelli J, De Schutter E, D'Angelo E (2007) Fast-reset of pacemaking and theta-frequency resonance patterns in cerebellar golgi cells: simulations of their impact in vivo. Front Cell Neurosci 1:4 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s): HCN1;
Transmitter(s):
Simulation Environment: NEURON; neuroConstruct (web link to model);
Model Concept(s): Activity Patterns; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it]; De Schutter, Erik [erik at oist.jp];
Search NeuronDB for information about:  I Na,p; I Na,t; I T low threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Files displayed below are from the implementation
/
Golgi_cell
sessions
readme.html
Golgi_BK.mod *
Golgi_Ca_HVA.mod *
Golgi_Ca_LVA.mod *
Golgi_CALC.mod *
Golgi_CALC_ca2.mod *
Golgi_hcn1.mod *
Golgi_hcn2.mod *
Golgi_KA.mod *
Golgi_KM.mod *
Golgi_KV.mod *
Golgi_lkg.mod *
Golgi_Na.mod *
Golgi_NaP.mod *
Golgi_NaR.mod *
Golgi_SK2.mod *
Pregen.mod *
Synapse.mod *
Channel_dynamics.hoc *
Golgi_ComPanel.hoc *
Golgi_count.txt
Golgi_template.hoc
mosinit.hoc
Save_data.hoc *
screenshot.jpg
Start_golgi.hoc
Synapses.hoc *
utils.hoc *
                            
TITLE Cerebellum Golgi Cell Model

COMMENT
        Calcium first order kinetics
   
	Author: A. Fontana
	Revised: 12.12.98
ENDCOMMENT

NEURON {
        SUFFIX Golgi_CALC_ca2
        USEION ca2 READ ica2, ca2o WRITE ca2i VALENCE 2
        RANGE d, beta, ca2i0, ca2_pump_i
}

UNITS {
        (mV)    = (millivolt)
        (mA)    = (milliamp)
	(um)    = (micron)
	(molar) = (1/liter)
        (mM)    = (millimolar)
   	F      = (faraday) (coulomb)
}

PARAMETER {
        ica2             (mA/cm2)
        celsius    (degC)
        d = .2          (um)
        ca2o        (mM)         
        ca2i0     (mM)         
        beta = 1.3        (/ms)
}
ASSIGNED {
	ca2_pump_i	(mA)
}

STATE {
	ca2i (mM)
}

INITIAL {
        ca2i = ca2i0 
}

BREAKPOINT {
       SOLVE conc METHOD derivimplicit
}

DERIVATIVE conc {    
	:  outward ionic current with valence 2+
	ca2_pump_i = 2*beta*(ca2i-ca2i0)
	:  total outward Ca2 current
	ca2i' = -ica2/(2*F*d)*(1e4) - beta*(ca2i-ca2i0)
}



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