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Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
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Accession:
112834
"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."
Reference:
1 .
Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron.
J Neurosci
25
:9080-95
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Nucleus accumbens spiny projection neuron;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I N;
I T low threshold;
I A;
I h;
I K,Ca;
I Krp;
I R;
I Q;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Schizophrenia;
Addiction;
Implementer(s):
Wolf, John A. [johnwolf at warpmail.net];
Moyer, Jason [jtmoyer at seas.upenn.edu];
Search NeuronDB
for information about:
GabaA
;
AMPA
;
NMDA
;
I Na,p
;
I Na,t
;
I L high threshold
;
I N
;
I T low threshold
;
I A
;
I h
;
I K,Ca
;
I Krp
;
I R
;
I Q
;
Download the displayed file
/
nacb_msp
tau_tables
CVS
tauh_car.txt
*
Other models using tauh_car.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_cat.txt
*
Other models using tauh_cat.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_kas.txt
*
Other models using tauh_kas.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_krp.txt
*
Other models using tauh_krp.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_naf.txt
*
Other models using tauh_naf.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_nap.txt
*
Other models using tauh_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_cat.txt
*
Other models using taum_cat.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kaf.txt
*
Other models using taum_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kas.txt
*
Other models using taum_kas.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kir.txt
*
Other models using taum_kir.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_krp.txt
*
Other models using taum_krp.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_naf.txt
*
Other models using taum_naf.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_car.txt
*
Other models using vtau_car.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_cat.txt
*
Other models using vtau_cat.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kaf.txt
*
Other models using vtau_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kas.txt
*
Other models using vtau_kas.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kir.txt
*
Other models using vtau_kir.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_krp.txt
*
Other models using vtau_krp.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_naf.txt
*
Other models using vtau_naf.txt:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_nap.txt
*
Other models using vtau_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
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