"... We present a single-compartment model of a CA3 hippocampal pyramidal neuron based on recent experimental data. We then use the model to determine the roles of primary depolarizing currents in burst generation.
The single compartment
model incorporates accurate representations of sodium (Na+) channels (NaV1.1) and T-type calcium (Ca2+) channel subtypes
(CaV3.1, CaV3.2, and CaV3.3).
Our simulations predict the importance of Na+ and T-type Ca2+ channels in hippocampal
pyramidal cell bursting and reveal the distinct contribution of each subtype to burst morphology.
We also performed fastslow
analysis in a reduced comparable model, which shows that our model burst is generated as a result of the interaction
of two slow variables, the T-type Ca2+ channel activation gate and the Ca2+-dependent potassium (K+) channel activation
gate.
The model reproduces a range of experimentally observed phenomena including afterdepolarizing potentials, spike widening at the end of the burst, and rebound.
Finally, we use the model to simulate the effects of two epilepsy-linked
mutations: R1648H in NaV1.1 and C456S in CaV3.2, both of which result in increased cellular excitability."
Reference:
1 .
Xu J, Clancy CE (2008) Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PLoS One 3:e2056 [PubMed]
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